Title:
エポキシドの合成方法
Document Type and Number:
Japanese Patent JP3871705
Kind Code:
B2
Abstract:
A process for synthesizing the epoxide of formula (I) consists of, at a minimum, formation of a halohydrin form the allyl acetonide reactant, followed by base-induced cyclization, the epoxide product (I) being useful as an intermediate for the synthesis of inhibitors of renin or HIV protease or other proteases.
Inventors:
Askin, David
En, Kang Kay
Marigress, Peter Yee
Raider, Paul Jei
Kei, Rothsen
Borant, Ralph Pee
Upatsudaiyai, Vena
En, Kang Kay
Marigress, Peter Yee
Raider, Paul Jei
Kei, Rothsen
Borant, Ralph Pee
Upatsudaiyai, Vena
Application Number:
JP52294995A
Publication Date:
January 24, 2007
Filing Date:
February 27, 1995
Export Citation:
Assignee:
Merck End Company, Inc.
International Classes:
C07D213/36; A61K31/44; C07D413/06; A61K31/4406; A61K31/4418; A61P31/12; A61P37/04; C07D263/52; C07D413/04; A61P31/18
Other References:
Tetrahedron Letters, 1994年,Vol.35, No.5, pp.673-676
J. Am. Chem. Soc., 1984年,Vol.106, pp.1079-1085
J. Am. Chem. Soc., 1984年,Vol.106, pp.1079-1085
Attorney, Agent or Firm:
Yoshio Kawaguchi
Toru Nakamura
Takeshi Funayama
Naoya Fushimi
Toru Nakamura
Takeshi Funayama
Naoya Fushimi