To obtain a new erythromycin compound having an excellent antibacterial activity against Helicobacter pylori, especially Helicobacter pylori showing resistance to other medicines, and also useful as an antiulcer agent.
This erythromycin derivative is expressed by formula I [wherein R1 is H or a lower alkyl; R2 is a (substituted) alkyl, a (substituted) heterocycle or the like; and R3 a (substituted) alkyl, a (substituted) cycloalkyl or the like] or its salt and is e.g. 5-O-desosaminyl-3-O-phenylacetylerythronolide A 9-[O-(1- methoxycyclohexyl)oxime], etc. The compound of formula I is obtained by reacting a compound of formula II (wherein R6 is H or a protecting group for OH group) with a carboxylic acid derivative expressed by the formula: R7-CO2H [wherein R7 is a (substituted) alkyl, a (substituted) heterocycle or the like] and a condensing agent in the presence of or in the absence of a base without or in a solvent and, if necessary, by performing deprotection.
KATO NORIYUKI
YOSHIDA TOSHIHIKO
NISHINO HIROYUKI
NISHIMOTO AKIYOSHI
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