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Title:
ESTER COMPOUND AND ITS MEDICINAL APPLICATION
Document Type and Number:
Japanese Patent JP3662566
Kind Code:
B2
Abstract:

PROBLEM TO BE SOLVED: To provide a new remedy for hyperlipemia substantially acting on MTP of the liver and hardly causing side effects such as fatty liver by selectively inhibiting the MTP in the small intestine.
SOLUTION: The ester compound represented by general formula (1) [wherein, R1 and R2 are each a hydrogen atom or an aryl group or the like which may be substituted; X is -COO- or -CON(R10)-; R3 and R4 are each a hydrogen atom, a 1-6C alkyl group, a 1-6C alkoxy group or the like; R5, R6 and R7 are each a hydrogen atom, a 1-6C alkyl group, a 1-6C alkoxy group or the like; R8 and R9 are the same or different, and each a hydrogen atom, a 1-6C alkyl group, -CON(R18) (R19, -COO(R20) or the like; ring A, ring B and ring C are the same or different and each an aryl ring, a heterocycle residue or the like; Alk1 and Alk2 are the same or different and each an alkanediyl or the like; and l and m are each 0 or an integer of 1-3), a prodrug or a pharmaceutically acceptable salt thereof is provided.


Inventors:
Atsushi Hagiwara
Yasuhiro Oe
Naoya Kotani
Shizue Watanabe
Taku Ikenoue
Takashi Kawai
Shinden Kenya
Toshio Taniguchi
Application Number:
JP2003053869A
Publication Date:
June 22, 2005
Filing Date:
February 28, 2003
Export Citation:
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Assignee:
Japan Tobacco Inc.
International Classes:
C07D295/12; A61K31/216; A61K31/235; A61K31/277; A61K31/381; A61K31/397; A61K31/40; A61K31/401; A61K31/4015; A61K31/402; A61K31/404; A61K31/4184; A61K31/423; A61K31/426; A61K31/44; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/4453; A61K31/4468; A61K31/5375; A61P3/04; A61P3/06; A61P3/10; A61P9/10; A61P43/00; C07C69/773; C07C233/81; C07C235/34; C07C235/40; C07C235/42; C07C235/56; C07C235/64; C07C235/84; C07C237/30; C07C237/40; C07C237/42; C07C255/57; C07C271/28; C07C311/04; C07D205/12; C07D207/16; C07D207/404; C07D209/08; C07D209/40; C07D211/58; C07D213/54; C07D213/61; C07D213/73; C07D213/82; C07D235/08; C07D239/20; C07D263/58; C07D277/20; C07D277/24; C07D277/28; C07D277/40; C07D277/56; C07D295/14; C07D295/16; C07D295/18; C07D333/24; (IPC1-7): C07C69/773; A61K31/216; A61K31/235; A61K31/277; A61K31/381; A61K31/397; A61K31/40; A61K31/401; A61K31/402; A61K31/404; A61K31/4184; A61K31/423; A61K31/426; A61K31/44; A61K31/4402; A61K31/4409; A61K31/4453; A61K31/4468; A61K31/5375; A61P3/04; A61P3/06; A61P3/10; A61P9/10; A61P43/00; C07C233/81; C07C235/42; C07C235/56; C07C235/64; C07C235/84; C07C237/30; C07C237/40; C07C255/57; C07C271/28; C07D205/12; C07D207/16; C07D209/40; C07D211/58; C07D213/54; C07D213/61; C07D213/73; C07D213/82; C07D235/08; C07D239/20; C07D263/58; C07D277/20; C07D277/24; C07D277/28; C07D277/56; C07D295/14; C07D295/18; C07D333/24
Foreign References:
WO1996040640A1
Attorney, Agent or Firm:
Ryu Iwatani