Title:
ESTER COMPOUND AND ITS MEDICINAL APPLICATION
Document Type and Number:
Japanese Patent JP3662566
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To provide a new remedy for hyperlipemia substantially acting on MTP of the liver and hardly causing side effects such as fatty liver by selectively inhibiting the MTP in the small intestine.
SOLUTION: The ester compound represented by general formula (1) [wherein, R1 and R2 are each a hydrogen atom or an aryl group or the like which may be substituted; X is -COO- or -CON(R10)-; R3 and R4 are each a hydrogen atom, a 1-6C alkyl group, a 1-6C alkoxy group or the like; R5, R6 and R7 are each a hydrogen atom, a 1-6C alkyl group, a 1-6C alkoxy group or the like; R8 and R9 are the same or different, and each a hydrogen atom, a 1-6C alkyl group, -CON(R18) (R19, -COO(R20) or the like; ring A, ring B and ring C are the same or different and each an aryl ring, a heterocycle residue or the like; Alk1 and Alk2 are the same or different and each an alkanediyl or the like; and l and m are each 0 or an integer of 1-3), a prodrug or a pharmaceutically acceptable salt thereof is provided.
Inventors:
Atsushi Hagiwara
Yasuhiro Oe
Naoya Kotani
Shizue Watanabe
Taku Ikenoue
Takashi Kawai
Shinden Kenya
Toshio Taniguchi
Yasuhiro Oe
Naoya Kotani
Shizue Watanabe
Taku Ikenoue
Takashi Kawai
Shinden Kenya
Toshio Taniguchi
Application Number:
JP2003053869A
Publication Date:
June 22, 2005
Filing Date:
February 28, 2003
Export Citation:
Assignee:
Japan Tobacco Inc.
International Classes:
C07D295/12; A61K31/216; A61K31/235; A61K31/277; A61K31/381; A61K31/397; A61K31/40; A61K31/401; A61K31/4015; A61K31/402; A61K31/404; A61K31/4184; A61K31/423; A61K31/426; A61K31/44; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/4453; A61K31/4468; A61K31/5375; A61P3/04; A61P3/06; A61P3/10; A61P9/10; A61P43/00; C07C69/773; C07C233/81; C07C235/34; C07C235/40; C07C235/42; C07C235/56; C07C235/64; C07C235/84; C07C237/30; C07C237/40; C07C237/42; C07C255/57; C07C271/28; C07C311/04; C07D205/12; C07D207/16; C07D207/404; C07D209/08; C07D209/40; C07D211/58; C07D213/54; C07D213/61; C07D213/73; C07D213/82; C07D235/08; C07D239/20; C07D263/58; C07D277/20; C07D277/24; C07D277/28; C07D277/40; C07D277/56; C07D295/14; C07D295/16; C07D295/18; C07D333/24; (IPC1-7): C07C69/773; A61K31/216; A61K31/235; A61K31/277; A61K31/381; A61K31/397; A61K31/40; A61K31/401; A61K31/402; A61K31/404; A61K31/4184; A61K31/423; A61K31/426; A61K31/44; A61K31/4402; A61K31/4409; A61K31/4453; A61K31/4468; A61K31/5375; A61P3/04; A61P3/06; A61P3/10; A61P9/10; A61P43/00; C07C233/81; C07C235/42; C07C235/56; C07C235/64; C07C235/84; C07C237/30; C07C237/40; C07C255/57; C07C271/28; C07D205/12; C07D207/16; C07D209/40; C07D211/58; C07D213/54; C07D213/61; C07D213/73; C07D213/82; C07D235/08; C07D239/20; C07D263/58; C07D277/20; C07D277/24; C07D277/28; C07D277/56; C07D295/14; C07D295/18; C07D333/24
Foreign References:
| WO1996040640A1 |
Attorney, Agent or Firm:
Ryu Iwatani