Title:
エストロゲン受容体モジュレーター
Document Type and Number:
Japanese Patent JP2004511501
Kind Code:
A
Abstract:
The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for treatment or prevention of a variety of conditions related to estrogen functioning including: bone loss, bone fractures, osteoporosis, cartilage degeneration, endometriosis, uterine fibroid disease, hot flashes, increased levels of LDL cholesterol, cardiovascular disease, impairment of cognitive functioning, cerebral degenerative disorders, restinosis, gynacomastia, vascular smooth muscle cell proliferation, obesity, incontinence, and cancer, in particular of the breast, uterus and prostate.
Inventors:
Frank Pea, Dinino
Kim, songkon
Woo, Jean Wye
Kim, songkon
Woo, Jean Wye
Application Number:
JP2002535612A
Publication Date:
April 15, 2004
Filing Date:
October 15, 2001
Export Citation:
Assignee:
MERCK & COMPANY INCOPORATED
International Classes:
C07D319/20; A61K31/357; A61K31/39; A61K31/453; A61K31/4535; A61K31/4545; A61P3/04; A61P3/06; A61P5/30; A61P9/00; A61P9/10; A61P9/14; A61P13/00; A61P15/00; A61P19/00; A61P19/04; A61P19/08; A61P19/10; A61P25/00; A61P25/28; A61P35/00; C07D327/06; C07D411/04; C07F7/18; (IPC1-7): C07F7/18; A61K31/357; A61K31/39; A61K31/453; A61K31/4535; A61K31/4545; A61P3/04; A61P3/06; A61P5/30; A61P9/00; A61P9/10; A61P9/14; A61P13/00; A61P15/00; A61P19/00; A61P19/04; A61P19/08; A61P19/10; A61P25/00; A61P25/28; A61P35/00; C07D319/20; C07D327/06; C07D411/04
Attorney, Agent or Firm:
Yoshio Kawaguchi
Mitsuru Inoue
Akio Ichiiri
Makoto Ono
Katsuma Osaki
Mitsuaki Tsubokura
Mitsuru Inoue
Akio Ichiiri
Makoto Ono
Katsuma Osaki
Mitsuaki Tsubokura