ETHANOL AMINE COMPOUND

Japanese Patent JPS62201851

A

The invention provides compounds of the general formula (I) wherein Ar represents a phenyl group optionally substituted by one or more substituents selected from halogen atoms, or the groups C1-6 alkyl, nitro, -(CH2)qR, [where R is hydroxy, C1-6 alkoxy, -NR<3>R<4> each represents a hydrogen atom, or a C1-4 alkyl group, or -NR<3>R<4> forms a saturated heterocyclic amino group which has 5-7 ring members and optionally contains in the ring one or more atoms selected from -O- or -S- or a group -NH- or -N(CH3)-), -NR<5>COR<6> (where R<5> represents a hydrogen atom or a C1-4 alkyl group, and R<6> represents a hydrogen atom or a C1-4 alkyl, C1-4 alkoxy, phenyl or -NR<3>R<4> group), -NR<5>SO2R (where R<7> represents a C1-4 alkyl, phenyl or -NR<3>R<4> group), -COR<8> (where R<8> represents hydroxy, C1-4 alkoxy or -NR<3>R<4>, -SR<9> (where R<9> is a hydrogen atom, or a C1-4 alkyl or phenyl group), -SOR<9>, -SO2R<9>, or -CN, and q represents an integer from 0 to 3], or -O(CH2)tR<1><1> [where R<1><1> represents a hydroxy or C1-4 alkoxy group and t is 2 or 3], or Ar is a phenyl group substituted by an alkylenedioxy group of formula -O(CH2)pO-, where p represents 1 or 2; R<1> and R<2> each represent a hydrogen atom or a C1-3 alkyl group, with the proviso that the sum total of carbon atoms in R<1> and R<2> is not more than 4; R<3><0> represents a hydrogen atom or a C1-3 alkyl group; X represents a C2-8 alkylene chain optionally substituted by one or two C1-3 alkyl groups, or, when one carbon atom is substituted by two methyl groups, they may be linked to form an ethylene group, and Y represents a C1-7 alkylene chain optionally substituted by one or two C1-3 alkyl groups, or, when one carbon atom is substituted by two alkyl groups, they may be linked to form an alkylene group; with the proviso that the sum total of carbon atoms in X and Y is 4 to 12; and with the further proviso that at least one of X and Y is substituted by one or two C1-3 alkyl groups or an alkylene group; Q represents (a) (where R<1><2> is a straight or branched C1-3 alkylene group), (where one or R<1><3> and R<1><4> is a hydroxy group and the other is a hydrogen or halogen atom or a hydroxy group), [where R<1><5> is a group R<1><6>CO-, R<1><6>NHCO-, R<1><6>R<1><7>NSO2- or R<1><8>SO2- (where R<1><6> and R<1><7> is each a hydrogen atom or a C1-3 alkyl group and R<1><8> is a C1-3 alkyl group) and p is an integer 0 or 1], (where R<2><6> and R<2><7> is each a hydrogen atom or a C1-3 alkyl group or, when R<2><6> is a hydrogen atom, R<2><7> may also be a C1-4 alkoxycarbonyl group), (where R<1><9> is a C1-3 alkyl group), and physiologically acceptable salts and solvates (e.g. hydrates) thereof. The compounds have a stimulant action at beta 2-adrenoreceptors and may be used in the treatment of diseases associated with reversible airways obstruction such as asthma and chronic bronchitis.

HARII FUINCHI
ROORENSU HENRII CHIYAARUZU RAN
ARAN NAIRAA
IAN FUREDERITSUKU SUKITSUDOMOA

JP24515186A

September 05, 1987

October 15, 1986

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GLAXO GROUP LTD

A61K31/135; A61K31/165; A61K31/19; A61K31/235; A61K31/275; A61K31/435; A61K31/47; A61P1/04; A61P9/00; A61P25/02; A61P25/24; A61P25/26; A61P27/02; A61P27/14; A61P29/00; A61P37/08; C07C67/00; C07C213/00; C07C217/10; C07C231/00; C07C231/12; C07C233/18; C07C233/25; C07C233/36; C07C233/43; C07C233/75; C07C235/42; C07C235/46; C07C239/00; C07C253/00; C07C255/37; C07C255/43; C07C271/16; C07C275/32; C07C301/00; C07C303/34; C07C303/40; C07C311/00; C07C313/00; C07C313/04; C07C313/12; C07C313/16; C07C317/22; C07C317/28; C07C323/12; C07D215/26; C07D295/08; (IPC1-7): A61K31/135; A61K31/165; A61K31/19; A61K31/235; A61K31/275; A61K31/435; A61K31/47; C07C89/00; C07C93/02; C07C103/26; C07C103/38; C07C103/44; C07C103/76; C07C121/75; C07C121/80; C07C125/063; C07C127/19; C07C143/72; C07C145/00; C07C147/10; C07C147/14; C07C149/36; C07D215/26; C07D295/08

Kazuo Sato

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