Title:
組織特異的疾患のイメージングのための、エチレンジシステイン(EC)-薬物結合体、組成物、および方法
Document Type and Number:
Japanese Patent JP2006515835
Kind Code:
A
Abstract:
The present invention relates to a radionuclide-labeled ethylenedicysteine (EC) derivative comprising a disease cell cycle targeting compound, wherein
(i) the EC forms an N 2 S 2 chelate with the radionuclide,
(ii) the disease cell cycle targeting compound is a nucleoside, or analog thereof, and is selected from guanine, adenosine, penciclovir, FIAU, FIRU, FMAU, IVFRU, GCV, PCV, FGCV, FPCV, FHPG, and FHBG; and
(iii)the disease cell cycle targeting compound is conjugated to EC directly or via a linker.
Inventors:
Yang, David Jay.
You, Don-Fan
Oh, Chang-Sok
Brian, Jerry El. Jr.
You, Don-Fan
Oh, Chang-Sok
Brian, Jerry El. Jr.
Application Number:
JP2004552132A
Publication Date:
June 08, 2006
Filing Date:
November 07, 2003
Export Citation:
Assignee:
BOARD OF REGENTS,THE UNIVERSITY OF TEXAS SYSTEM
International Classes:
A61K51/00; A61K47/02; A61K47/12; A61K47/22; A61K47/24; A61K47/26; A61K49/00; A61K51/08; A61K51/10; A61M36/14; C07C323/63; C07D211/88; C07D213/66; C07D231/12; C07D239/94; C07D519/00; C07F5/00; C07F13/00; C07H19/06; C07H19/16; C07K14/59; C07K14/71; C07K14/765; C07K14/79; C07K16/28; C07K16/46; C07B59/00; A61K; C12Q
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita