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Title:
ETHYLENEDICYSTEINE (EC)-DRUG CONJUGATE
Document Type and Number:
Japanese Patent JP2008208138
Kind Code:
A
Abstract:

To overcome prior art defects and other defects by providing a new radiolabeling strategy for targeting the tissue for imaging.

A radiolabeled tissue-specific ligand, a method for preparing this radiolabeled ligand, a method of using this radiolabeled ligand for imaging tissue-specific diseases, and a composition for imaging tissue-specific diseases are provided. This imaging composition typically comprises ethylenedicysteine and a radionuclide label which is conjugated to the ethylenedicysteine on one or both acid arms and is chelated with a tissue-specific ligand. This ethylenedicysteine forms an N2S2 chelate having the radionuclide label. Naturally, this chelate compound contains an ionic bond between the radionuclide and the chelate compound.


Inventors:
YANG DAVID J
LIU CHUN-WEI
YU DONG-FANG
KIM E EDMUND
Application Number:
JP2008123946A
Publication Date:
September 11, 2008
Filing Date:
May 09, 2008
Export Citation:
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Assignee:
UNIV TEXAS
International Classes:
A61K51/00; A61K51/04; C07D233/91; A61K51/08; C07D233/92; C07D409/12; C07D475/04; C07D475/06; C07H23/00
Domestic Patent References:
JPH1036293A1998-02-10
JP2003534388A2003-11-18
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita



 
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