Title:
Ethynyl derivative
Document Type and Number:
Japanese Patent JP6134441
Kind Code:
B2
Abstract:
It has been surprisingly been found that the compounds of general formula I are positive allosteric modulators (PAMs) of metabotropic glutamate receptor 4 (mGluR4), useful for the treatment of Parkinson's disease, anxiety, emesis, obsessive compulsive disorder, autism, neuroprotection, cancer, depression and diabetes type 2.
Inventors:
Beamance, Barbara
Gouva, Wolfgang
Jaschke, Georg
Rich, Antonio
Daniel, Ruel
Eric, Fieira
Gouva, Wolfgang
Jaschke, Georg
Rich, Antonio
Daniel, Ruel
Eric, Fieira
Application Number:
JP2016517337A
Publication Date:
May 24, 2017
Filing Date:
September 22, 2014
Export Citation:
Assignee:
F. HOFFMANN-LA ROCHE AKTIENGESELLSCHAFT
International Classes:
A61K31/517; C07D239/96; A61K31/519; A61K31/522; A61K31/5377; A61P1/08; A61P25/00; A61P25/16; A61P25/22; A61P25/24; A61P35/00; C07D401/04; C07D401/10; C07D405/04; C07D405/14; C07D471/04; C07D473/10; C07D475/02; C07D487/04; C07D487/06; C07D495/04; C07D513/04
Domestic Patent References:
| JP2013523854A | ||||
| JP2013526544A | ||||
| JP2013519685A | ||||
| JP2013503909A |
Foreign References:
| WO2013050454A1 |
Attorney, Agent or Firm:
Patent business corporation Tsukuni