自然免疫機構を活性化/抑制する作用を有する物質の評価方法及びスクリーニング方法、並びに、自然免疫機構を活性化/抑制するための薬剤、食品及びそれらの製造方法 - Genome Drug Discovery Research Institute Co., Ltd.

Title:

自然免疫機構を活性化/抑制する作用を有する物質の評価方法及びスクリーニング方法、並びに、自然免疫機構を活性化/抑制するための薬剤、食品及びそれらの製造方法

Document Type and Number:

Japanese Patent JP5394233

Kind Code:

B2

Abstract:

It is intended to provide an evaluation method and a screening method capable of eliminating a substance that disturbs in vivo kinetics in an individual and capable of simply and easily searching a substance having an action of activating/suppressing an innate immune mechanism without being affected by LPS derived from bacteria, which can be contaminated during the search, as well as a drug and a food for activating/suppressing the innate immune mechanism, and methods of producing the same. The present invention provides a method of evaluating or screening the substance having the action of activating/suppressing the innate immune mechanism using a muscular contraction of an organism having the innate immune mechanism as an indicator, and methods of producing the drug and the food for activating/suppressing the innate immune mechanism. Also, an innate immunity activator and the food having the action of activating the innate immune mechanism containing the substance having the action of contracting the muscle of the organism having the innate immune mechanism, and an innate immunity suppressor and the food having the action of suppressing the innate immunity containing the substance having the action of suppressing the contraction of the muscle of the organism having the innate immune mechanism are provided.

Inventors:

Kazuhisa Sekimizu
Hiroshi Hamamoto

Application Number:

JP2009509376A

Publication Date:

January 22, 2014

Filing Date:

April 10, 2008

Export Citation:

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Assignee:

Genome Drug Discovery Research Institute Co., Ltd.
National University Corporation Tokyo University
Imagine Global Care Co., Ltd.

International Classes:

G01N33/50; A23L1/30; A23L33/10; A23L33/105; A61K35/64; A61K36/18; A61K36/23; A61K36/28; A61K36/31; A61K36/42; A61K36/81; A61K36/896; A61K36/8962; A61K45/00; A61P37/02; A61P37/04; G01N33/15; A61K125/00

Foreign References:

WO2001086287A1	2001-11-15
WO2001086287A1	2001-11-15

Other References:

JPN6013018207; Ｊ　Ｃａｎｃｅｒ　Ｒｅｓ　Ｃｌｉｎ　ＯｎｃｏｌＶｏｌ．１１８，　Ｎｏ．６，　Ｐａｇｅ．４４７-４５２, 1992
JPN6013018210; Ｊ　ＢｉｏｃｈｅｍＶｏｌ．１３７，　Ｎｏ．２，　Ｐａｇｅ．１９９-２０３, 2005
JPN6013018212; Ｊ　ＮｅｕｒｏｃｈｅｍＶｏｌ．９５，　Ｎｏ，４，　Ｐａｇｅ．９１３-９１８, 2005
JPN6013018214; Ｊ　Ｂｉｏｌ　Ｃｈｅｍ，　２００８．０１．２５，　Ｖｏｌ．２８３，Ｎｏ．４，　Ｐａｇｅ．２１８５-２１９１
JPN6013018215; Ｉｎｓｅｃｔ　Ｂｉｏｃｈｅｍ　Ｍｏｌ　Ｂｉｏｌ，１９９９，　Ｖｏｌ．２９，　Ｎｏ．１２，　Ｐａｇｅ．１０７５-１０８６
JPN6013018218; Ｅｕｒ　Ｊ　Ｐｈａｒｍａｃｏｌ，　１９９０，　Ｖｏｌ．１８５，　Ｎｏ．２／３，Ｐａｇｅ．１６９-１７８
JPN6013018221; Ａｒｃｈ　ＩｎｓｅｃｔＢｉｏｃｈｅｍ　Ｐｈｙｓｉｏｌ，　１９９６，　Ｖｏｌ．３３，　Ｎｏ．２，　Ｐａｇｅ．１６３-１８０
JPN6013018205; 和合治久、後藤清，　養魚への免疫賦活物質利用の可能性　「混合飼料Ｂ」，　養殖，　１９９８，　Ｖｏｌ．３５，　Ｎｏ．１，　Ｐａｇｅ．１１
JPN6013018207; Ｊ　Ｃａｎｃｅｒ　Ｒｅｓ　Ｃｌｉｎ　ＯｎｃｏｌＶｏｌ．１１８，　Ｎｏ．６，　Ｐａｇｅ．４４７-４５２, 1992
JPN6013018210; Ｊ　ＢｉｏｃｈｅｍＶｏｌ．１３７，　Ｎｏ．２，　Ｐａｇｅ．１９９-２０３, 2005
JPN6013018212; Ｊ　ＮｅｕｒｏｃｈｅｍＶｏｌ．９５，　Ｎｏ，４，　Ｐａｇｅ．９１３-９１８, 2005
JPN6013018214; Ｊ　Ｂｉｏｌ　Ｃｈｅｍ，　２００８．０１．２５，　Ｖｏｌ．２８３，Ｎｏ．４，　Ｐａｇｅ．２１８５-２１９１
JPN6013018215; Ｉｎｓｅｃｔ　Ｂｉｏｃｈｅｍ　Ｍｏｌ　Ｂｉｏｌ，１９９９，　Ｖｏｌ．２９，　Ｎｏ．１２，　Ｐａｇｅ．１０７５-１０８６
JPN6013018218; Ｅｕｒ　Ｊ　Ｐｈａｒｍａｃｏｌ，　１９９０，　Ｖｏｌ．１８５，　Ｎｏ．２／３，Ｐａｇｅ．１６９-１７８
JPN6013018221; Ａｒｃｈ　ＩｎｓｅｃｔＢｉｏｃｈｅｍ　Ｐｈｙｓｉｏｌ，　１９９６，　Ｖｏｌ．３３，　Ｎｏ．２，　Ｐａｇｅ．１６３-１８０

Attorney, Agent or Firm:

Tokuaki Takahashi

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