EXOSOMES COMPRISING RNA THERAPEUTICS

Title:

EXOSOMES COMPRISING RNA THERAPEUTICS

Document Type and Number:

Japanese Patent JP2022113690

Kind Code:

A

Abstract:

To overcome problems identified herein associated with loading and subsequent EV-mediated delivery of nucleic acid (NA)-based therapeutics into target cells, and to satisfy the existing needs in the art, e.g., to make it possible to reach a proper intracellular compartment with an NA therapeutic agent in question.SOLUTION: The present invention pertains to extracellular vesicle (EV) therapeutics, where the EVs comprise nucleic acid (NA)-based therapeutics such as mRNAs, circular RNAs, miRNAs, shRNAs, and circular RNA and/or DNA molecules. The NA therapeutics are loaded into EVs using inventive protein and NA engineering strategies to enhance loading into EVs and to facilitate release of NA cargo molecules inside target cells.SELECTED DRAWING: None

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Inventors:

LORENZO ERRICHELLI
DHANU GUPTA
JUSTIN HEAN
JOEL NORDIN

Application Number:

JP2022080936A

Publication Date:

August 04, 2022

Filing Date:

May 17, 2022

Export Citation:

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Assignee:

EVOX THERAPEUTICS LTD

International Classes:

C12N5/10; C12N1/02; C12N5/02; C12N5/077; C12N15/11; C12N15/113; C12N15/88

Foreign References:

WO2015002956A1

2015-01-08

Attorney, Agent or Firm:

Murayama Yasuhiko
Shinya Mihiro
Tatsuhiko Abe

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