Title:
EXPRESSION VECTOR AND CELL LINE EXPRESSING VASCULAR ENDOTHELIAL GROWTH FACTOR D, AND METHOD OF TREATING MELANOMAS
Document Type and Number:
Japanese Patent JP2009159972
Kind Code:
A
Abstract:
To provide expression vectors comprising vascular endothelial growth factor D (VEGF-D) and its biologically active derivatives, cell lines stably expressing VEGF-D and its biologically active derivatives, and to provide a method of making a polypeptide using these expression vectors and host cells.
Disclosed are expression vectors comprising VEGF-D and its biologically active derivatives, the cell lines stably expressing VEGF-D and its biologically active derivatives, the method of making a polypeptide using these expression vectors and host cells, and a method of treating and alleviating melanomas or tumors expressing VEGF-D and various diseases.
Inventors:
ACHEN MARC G
STACKER STEVEN A
ALITALO KARI
STACKER STEVEN A
ALITALO KARI
Application Number:
JP2009046292A
Publication Date:
July 23, 2009
Filing Date:
February 27, 2009
Export Citation:
Assignee:
LUDWIG INST CANCER RES
International Classes:
C12N15/09; A61K31/7088; A61K38/00; A61K38/19; A61K39/395; A61K45/00; A61K48/00; A61P7/00; A61P17/00; A61P17/02; A61P17/06; A61P35/00; A61P43/00; C07K14/52; C07K16/22; C12N5/10; C12P21/02; G01N33/574
Domestic Patent References:
| JP2003517265A | 2003-05-27 |
Attorney, Agent or Firm:
Shuichiro Kitamura