PURPOSE: To obtain a pridinol mesilate-containing external preparation excellent in percutaneous absorbability and useful as a skeletal muscle relaxant.
CONSTITUTION: Pridinol mesilate is compounded with glycerol and benzylalcohol preferably in amounts of 1-50wt.% and 1-20wt.%, respectively. The external preparation is preferably formed into a plaster. The simultaneous use of the benzylalcohol and the glycerol as percutaneous absorption-promoting agents gives such the high percutaneous absorption of the pridinol mesilate as being not given by the simultaneous use of propylene glycol or 1,3-butylene glycol. When the glycerol is compounded in a large amount, the percutaneous absorption of the pridinol mesilate is lowered, while when compounded in a small amount, the dispersibility of the pridinol mesilate is deteriorated on the formation of the medicinal preparation to lower workability and uniformity. The external preparation is excellent in percutaneous absorbability, maintains an effective concentration in blood for a long time, can easily be used, and is little in side effects.
WADA YOSHIO
YAMADA YOSHIHARU
MIZUNO KEIZO
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