Title:
FA-70C1 SUBSTANCE
Document Type and Number:
Japanese Patent JP3643925
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To obtain a new compound FA-70C1 capable of being isolated from culture products of microorganisms belonging to Actinomycetes and capable of manifesting excellent inhibitory activity to cathepsin protease and Arg- gingipain.
SOLUTION: This new compound is a FA-70C1 substance expressed by the formula or its salt. The FA-70C1 substance has the following physicochemical properties: (1) assuming the form of white powder; (2) having the empirical formula C27H43N9O7; (3) having 605.69 molecular weight; (4) readily soluble in methanol, dimethyl sulfoxide and acetonitrile, slightly soluble in ethanol and difficultly soluble in chloroform, acetone, ethyl acetate, ether and hexane; (5) decomposing at ≥250°C; (6) showing coloration in Ehrlich's reaction and Sakaguchi's reaction and assuming no color in ninhydrin reaction. The FA-70C1 substance of the formula is obtained by culturing bacteria belonging to Streptomyces and having the ability to produce the substance and by collecting the substance from the resultant culture products.
Inventors:
Kitano Shizuo
Kenichiro Yoshida
Nobuhiko Katsunuma
Kenji Yamamoto
Kenichiro Yoshida
Nobuhiko Katsunuma
Kenji Yamamoto
Application Number:
JP25454098A
Publication Date:
April 27, 2005
Filing Date:
August 24, 1998
Export Citation:
Assignee:
Taiho Pharmaceutical Co., Ltd.
International Classes:
A61K8/00; A61K8/49; A61K8/66; A61K8/99; A61K31/00; A61K38/55; A61P1/00; A61P1/02; A61P19/10; A61P21/04; A61P31/00; A61P31/04; A61P35/04; A61Q11/00; C07K5/083; C12N9/99; (IPC1-7): C07K5/083; A61K7/16; A61K31/00; A61K38/55; A61P19/10; A61P21/04; A61P35/04; C12N9/99
Attorney, Agent or Firm:
Eiji Saegusa
Kakehi Yuro
Takeshi Ohara
Hiroji Nakagawa
Yasumitsu Tate
Kenji Saito
Jun Fujii
Hitoshi Seki
Mutsuko Nakano
Shinsuke Otsuki
Suzuki Katsuto
Kakehi Yuro
Takeshi Ohara
Hiroji Nakagawa
Yasumitsu Tate
Kenji Saito
Jun Fujii
Hitoshi Seki
Mutsuko Nakano
Shinsuke Otsuki
Suzuki Katsuto