Title:
凝血活性が増加した第VII因子または第VIIa因子変種
Document Type and Number:
Japanese Patent JP4472526
Kind Code:
B2
Abstract:
The present invention relates to novel Factor VII or VIIa variants comprising a substitution in at least one position selected from the group consisting of L39, 142, S43, K62, L65, F71, E82 and F275. Such variants exhibit increased clotting activity as compared to human wild-type Factor VIIa. The present invention also relates to use of such Factor VII or VIIa variants in therapy, in particular for the treatment of a variety of coagulation-related disorders.
Inventors:
Harning Jesper Mortensen
Andersen Kim Bilbo
Andersen Kim Bilbo
Application Number:
JP2004538776A
Publication Date:
June 02, 2010
Filing Date:
September 26, 2003
Export Citation:
Assignee:
BAYER HEALTHCARE
International Classes:
C12N15/09; A61K38/43; A61P7/04; A61P17/02; A61P41/00; A61P43/00; C07K14/745; C12N1/15; C12N1/19; C12N5/10; C12N9/64; A61K38/00
Foreign References:
| WO2001058935A1 | ||||
| WO2002038162A1 |
Other References:
DICKINSON, C.D. et al.,"Identification of surface residues mediating tissue factor binding and catalytic function of the serine protease factor VIIa.",PROC. NATL. ACAD. SCI. USA,1996年12月,Vol.93, No.25,p.14379-14384
CHEUNG, W.-F. et al.,"Localization of a metal-dependent epitope to the amino terminal residues 33?40 of human factor IX.",THROMBOSIS RESEARCH,1995年12月,Vol.80, No.5,p.419-427
CHEUNG, W.-F. et al.,"Localization of a metal-dependent epitope to the amino terminal residues 33?40 of human factor IX.",THROMBOSIS RESEARCH,1995年12月,Vol.80, No.5,p.419-427
Attorney, Agent or Firm:
Hatsushi Shimizu
Toshi Gobe
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Ryuichi Inoue
Masato Ozeki
Toshi Gobe
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Ryuichi Inoue
Masato Ozeki