Title:
第ＸＩＡ因子インヒビター
Document Type and Number:
Japanese Patent JP2017517512
Kind Code:
A
Abstract:
本発明は、式Ｉ【化１】の化合物、および１以上の該化合物を含む医薬組成物、および血栓症、塞栓症、凝固性亢進または線維性変化の治療または予防のための該化合物の使用方法を提供する。該化合物は選択的第ＸＩａ因子インヒビターまたは第ＸＩａ因子と血漿カリクレインとの二重インヒビターである。
Inventors:
Liu, Wei Guo
Scott Dee, Edmondson
Guo, Shu Yang
Mart, eric
Ogawa, Anthony Kay
Seo, Sung-Sau
Sun, One Inn
Block Unil, Linda El.
Ali, Amjad
Quan, Ronzo
Wu, Hopin
Scott Dee, Edmondson
Guo, Shu Yang
Mart, eric
Ogawa, Anthony Kay
Seo, Sung-Sau
Sun, One Inn
Block Unil, Linda El.
Ali, Amjad
Quan, Ronzo
Wu, Hopin
Application Number:
JP2016569375A
Publication Date:
June 29, 2017
Filing Date:
May 22, 2015
Export Citation:
Assignee:
Merck Sharp & Dohme Corp.
International Classes:
C07D213/89; A61K31/4425; A61K31/4439; A61P7/02; A61P43/00; C07D401/10; C07D401/12; C07D401/14
Domestic Patent References:
| JP2008502692A | 2008-01-31 | |||
| JP2010529991A | 2010-09-02 | |||
| JP2008536918A | 2008-09-11 |
Foreign References:
| US7829584B2 | 2010-11-09 | |||
| WO2013009527A2 | 2013-01-17 |
Attorney, Agent or Firm:
Makoto Ono
Kenkyo Kanayama
Mitsuaki Tsubokura
Kazuki Shigemori
Kenji Ando
Hidehiko Ichikawa
Takahiro Aoki
Yoshie Sakurada
Yousuke Kawasaki
Takuya Gomibuchi
Toshikazu Imato
Yoichi Iino
Yusuke Ichikawa
Masahiro Moriyama
Yoshikazu Iwase
Yasufumi Shiroyama
Kenkyo Kanayama
Mitsuaki Tsubokura
Kazuki Shigemori
Kenji Ando
Hidehiko Ichikawa
Takahiro Aoki
Yoshie Sakurada
Yousuke Kawasaki
Takuya Gomibuchi
Toshikazu Imato
Yoichi Iino
Yusuke Ichikawa
Masahiro Moriyama
Yoshikazu Iwase
Yasufumi Shiroyama