Fc受容体調節化合物および組成物

Japanese Patent JP2006516133

A

The present invention provides compounds capable of binding to an Fc receptor and modulating Fc receptor activity comprising a core lipophilic group in the form of an Aryl zing substituted with a group rich in p-electrons. The invention further provides for a method of treating an autoimmune disease involving Fc receptor activity using such compounds. A method for obtaining a compound which modulates Fc receptor activity is also provided, the method comprising: (a) providing or designing compounds having structural characteristics to fit in the groove of the FcγRIIa structure; and (b) screening the compounds for modulating activity on the Fc receptor.

Philip Mark Hogarth
Jeffrey Alan Peters
Gerald Peter Moloney

JP2004562392A

June 22, 2006

December 24, 2003

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Arthur Limited

C07C65/38; A61K31/12; A61K31/165; A61K31/19; A61K31/192; A61K31/194; A61K31/195; A61K31/197; A61K31/27; A61K31/275; A61K31/336; A61K31/381; A61K31/40; A61K31/41; A61K31/4166; A61K31/4196; A61K31/426; A61K38/00; A61P1/04; A61P7/04; A61P7/06; A61P19/02; A61P29/00; A61P37/00; A61P37/02; A61P43/00; C07C57/42; C07C59/68; C07C62/38; C07C63/66; C07C69/618; C07C229/60; C07C233/05; C07C233/11; C07C251/24; C07C251/86; C07C255/41; C07C271/22; C07C275/24; C07C275/42; C07C317/44; C07C323/22; C07C323/56; C07C323/60; C07C323/62; C07C323/63; C07D207/08; C07D207/333; C07D249/14; C07D255/02; C07D277/20; C07D277/36; C07D303/38; C07D333/70; C07D409/12; C07D409/14; C07K5/06; C07K5/083; C07D207/32

JP2003252794A	2003-09-10
JPS6156175A	1986-03-20
JPS51125736A	1976-11-02
JPH06340580A	1994-12-13
JPH10147568A	1998-06-02
JP2002503227A	2002-01-29
JPH0892191A	1996-04-09
JPH03275657A	1991-12-06
JP2002524504A	2002-08-06

WO2002042289A2	2002-05-30
WO2002002522A1	2002-01-10
WO2001090747A2	2001-11-29

Masatake Shiga
Takashi Watanabe
Yasuhiko Murayama
Shinya Mitsuhiro

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