Title:
発酵法
Document Type and Number:
Japanese Patent JP2013501511
Kind Code:
A
Abstract:
The present invention relates to a fermentation process for culturing a host cell comprising a vector which comprises an inducible promoter of the mannose operon wherein the inducible promoter of the mannose operon controls expression of a nucleic acid sequence encoding for a polypeptide, in particular the present invention relates to the high cell density fermentation of a prokaryotic host cell comprising the inducible promoter of the mannose operon in the production of a polypeptide.
Inventors:
Marian Wenzel
Josef Alten Buchner
Christoph Kitziak
Martin Zieman-Hertsbeark
Josef Alten Buchner
Christoph Kitziak
Martin Zieman-Hertsbeark
Application Number:
JP2012524192A
Publication Date:
January 17, 2013
Filing Date:
August 02, 2010
Export Citation:
Assignee:
Lonza Age
International Classes:
C12N1/20; C12N1/21; C12N15/09; C12P21/02
Domestic Patent References:
| JP2008545436A | 2008-12-18 |
Foreign References:
| WO2004033633A2 | 2004-04-22 |
Other References:
JPN6014046996; Ｔｉａｎｑｉ Ｓｕｎ ａｎｄ Ｊｏｓｅｆ Ａｌｔｅｎｂｕｃｈｎｅｒ: Ｊｏｕｒｎａｌ ｏｆ Ｂａｃｔｅｒｉｏｌｏｇｙ Ｖｏｌ． １９２， Ｎｏ． ８, 20100205, ＰＰ． ２１２８-２１３９
JPN6014043900; ＮＡＴＵＲＥ ｖｏｌ．３９０, 1997, ｐｐ．２４９-２５６
JPN6014043902; Ａｎｎｕ． Ｒｅｖ． Ｍｉｃｒｏｂｉｏｌ． ｖｏｌ．５４, 2000, ｐｐ．８４９-８８０
JPN6014043904; ＪＯＵＲＮＡＬ ＯＦ ＢＡＣＴＥＲＩＯＬＯＧＹ ｖｏｌ．１７８ ｎｏ．２４, 1996, ｐｐ．７１１２-７１１９
JPN6014043905; Ｍｉｃｒｏｂｉｏｌｏｇｙ ｖｏｌ．１４５, 1999, ｐｐ．３４１９-３４２９
JPN6014043900; ＮＡＴＵＲＥ ｖｏｌ．３９０, 1997, ｐｐ．２４９-２５６
JPN6014043902; Ａｎｎｕ． Ｒｅｖ． Ｍｉｃｒｏｂｉｏｌ． ｖｏｌ．５４, 2000, ｐｐ．８４９-８８０
JPN6014043904; ＪＯＵＲＮＡＬ ＯＦ ＢＡＣＴＥＲＩＯＬＯＧＹ ｖｏｌ．１７８ ｎｏ．２４, 1996, ｐｐ．７１１２-７１１９
JPN6014043905; Ｍｉｃｒｏｂｉｏｌｏｇｙ ｖｏｌ．１４５, 1999, ｐｐ．３４１９-３４２９
Attorney, Agent or Firm:
Takuya Kuno
Takahashi
Kiyoshi Kuruma
Kimihiro Hoshi
Hiroyasu Ninomiya
Shuichi Sumiyoshi
Ryoichi Shino
Ueshima
Yasushi Miyagi
Einzel Felix-Reinhard
Takahashi
Kiyoshi Kuruma
Kimihiro Hoshi
Hiroyasu Ninomiya
Shuichi Sumiyoshi
Ryoichi Shino
Ueshima
Yasushi Miyagi
Einzel Felix-Reinhard