Title:
伸長α鎖を有するフィブリノーゲンが濃縮されたフィブリノーゲン調製物
Document Type and Number:
Japanese Patent JP5960606
Kind Code:
B2
Abstract:
The present invention relates to fibrinogen preparations enriched in α-extended fibrinogen. Compositions comprising such preparations show improved clotting properties compared to preparations based on HMW Fib which typically contain no or only low amounts of α-extended fibrinogen. In particular, clot formation time and the clot strength of a clot made by α-extended fibrinogen are improved. In addition, plasmin-mediated degradation of α-extended fibrinogen is reduced as compared to plasma derived fibrinogen.
Inventors:
Grimbergen, Joseph
Coopman, Jacob
Bout, Abraham
Coopman, Jacob
Bout, Abraham
Application Number:
JP2012547516A
Publication Date:
August 02, 2016
Filing Date:
January 07, 2011
Export Citation:
Assignee:
Profibrix bee buoy
International Classes:
C07K14/75; A61K38/43; A61K38/48; A61P7/04; A61P17/02; A61P41/00; C12N9/74; C12N15/09
Domestic Patent References:
| JP11507525A | ||||
| JP2005538045A |
Foreign References:
| WO2005010178A1 |
Other References:
LUDDINGTON, R.J.,Clin. Lab. Haem.,2005年,Vol.27,pp.81-90
GRIENINGER, G., et al.,FIB420, THE NOVEL FIBRINOGEN SUBCLASS: NEWBORN LEVELS ARE HIGHER THAN ADULT,BLOOD,米国,AMERICAN SOCIETY OF HEMATOLOGY,1997年,Vol.90, No.7,pp.2609-2614
MOSESSON, M.W., et al.,THE ULTRASTRUCTURE OF FIBRINOGEN-420 AND THE FIBRIN-420 CLOT,BIOPHYSICAL CHEMISTRY,NL,2004年,Vol.112, No.2-3,pp.209-214
FU, Y., et al.,Proc. Nati. Acad. Sci. USA,1994年 3月,Vol.91,pp.2625-2628
GRIENINGER, G., et al.,FIB420, THE NOVEL FIBRINOGEN SUBCLASS: NEWBORN LEVELS ARE HIGHER THAN ADULT,BLOOD,米国,AMERICAN SOCIETY OF HEMATOLOGY,1997年,Vol.90, No.7,pp.2609-2614
MOSESSON, M.W., et al.,THE ULTRASTRUCTURE OF FIBRINOGEN-420 AND THE FIBRIN-420 CLOT,BIOPHYSICAL CHEMISTRY,NL,2004年,Vol.112, No.2-3,pp.209-214
FU, Y., et al.,Proc. Nati. Acad. Sci. USA,1994年 3月,Vol.91,pp.2625-2628
Attorney, Agent or Firm:
Ryoichi Takaoka
Nao Oda
Nao Oda