Title:
ミオスタチンと結合するフィブロネクチンベースの足場ドメインタンパク質
Document Type and Number:
Japanese Patent JP6793680
Kind Code:
B2
Abstract:
The present invention relates to fibronectin-based scaffold domain proteins that bind to myostatin. The invention also relates to the use of these proteins in therapeutic applications to treat muscular dystrophy, cachexia, sarcopenia, osteoarthritis, osteoporosis, diabetes, obesity, COPD, chronic kidney disease, heart failure, myocardial infarction, and fibrosis. The invention further relates to cells comprising such proteins, polynucleotides encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the proteins.
More Like This:
Inventors:
Sharon Claude
Linda Engle
Dartha Lipovsek
Maravi Maddy Lady
Ginger Chao Lake Straw
Joanna Swain
Wen Jun Jiao
Hoi Wei
Aaron P. Yamunuk
Vidyashankar Lamamurti
Alexander T. Kozic
Martin Jay Corbett
Stanley Richard Cristech Jr.
Linda Engle
Dartha Lipovsek
Maravi Maddy Lady
Ginger Chao Lake Straw
Joanna Swain
Wen Jun Jiao
Hoi Wei
Aaron P. Yamunuk
Vidyashankar Lamamurti
Alexander T. Kozic
Martin Jay Corbett
Stanley Richard Cristech Jr.
Application Number:
JP2018101646A
Publication Date:
December 02, 2020
Filing Date:
May 28, 2018
Export Citation:
Assignee:
BRISTOL-MYERS SQUIBB COMPANY
International Classes:
C07K14/78; A61K38/39; A61K39/395; A61K47/42; A61K47/50; C12N15/12
Domestic Patent References:
| JP2012512641A | ||||
| JP2003525487A |
Foreign References:
| WO2011130354A1 | ||||
| WO2012088006A1 |
Other References:
LIPOVSEK D.,PROTEIN ENGINEERING DESIGN & SELECTION,2011年 1月,V24 N1-2,P3-9
EMANUEL STUART L.,MABS,2011年 1月,V3 N1,P38-48
EMANUEL STUART L.,MABS,2011年 1月,V3 N1,P38-48
Attorney, Agent or Firm:
Norihito Yamao
Kenji Tomita
Fumio Inai
Manami Sasakura
Kenji Tomita
Fumio Inai
Manami Sasakura