Title:
蛍光標識多糖、およびその調製方法と用途
Document Type and Number:
Japanese Patent JP7093524
Kind Code:
B2
Abstract:
Disclosed is a fluorescently labeled polysaccharide. The fluorescently labeled polysaccharide is formed by covalently coupling a polysaccharide to a fluorescent dye having a structure as shown in Formula I. A stable covalent bond is form between the polysaccharide molecule and the fluorescent dye molecule. The fluorescently labeled polysaccharide has high stability in serum and other detection environments, has high biocompatibility, and is applicable to the detection of carbohydrate molecules inside and outside cells. Due to a large Stokes shift of the fluorescent dye molecule, the fluorescently labeled polysaccharide has advantages of high fluorescence stability, high fluorescence quantum yields, and achieves high signal-to-noise ratios in imaging results. Further disclosed is a method for preparing the fluorescently labeled polysaccharide. The method has mild reaction conditions and high reaction selectivity, is simple to execute, and can be used to prepare a fluorescently labeled polysaccharide in high yield.
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Inventors:
Car unity
Application Number:
JP2019526322A
Publication Date:
June 30, 2022
Filing Date:
June 12, 2018
Export Citation:
Assignee:
Suzhou Hyakugen Basic Technology Co., Ltd.
International Classes:
C08B15/00; A61K51/06; C08B31/00; C08B37/00; C08B37/06; C08B37/08
Domestic Patent References:
| JP2017031394A | ||||
| JP62036469A | ||||
| JP5559529B2 |
Foreign References:
| CN104893710A | ||||
| CN1702118A |
Attorney, Agent or Firm:
Isono International Patent and Trademark Office