Title:
腫瘍の可視化、組織工学、および癌化学療法におけるフッ化炭水化物およびそれらの使用
Document Type and Number:
Japanese Patent JP2009530311
Kind Code:
A
Abstract:
The present invention relates to fluorine-containing monosaccharides that are useful for forming extracellular fluorinated glycoconjugates. Methods of forming extracellular fluorinated glycoconjugates comprise the steps of contacting a cell with a fluorine-containing monosaccharide, and incubating the cell under conditions whereby the cell internalizes the fluorine-containing monosaccharide, or a derivative thereof, on the surface of the cell. The present invention also relates to the use of a fluorine-containing monosaccharide in cellular imaging using fluorine NMR. The invention additionally relates to the use of fluorine containing monosaccharides in the treatment of cancer and inflammatory disease.
Inventors:
Kumar, Krishna
Dollar Khao, Mark
Deirak, Leila
Dollar Khao, Mark
Deirak, Leila
Application Number:
JP2009500605A
Publication Date:
August 27, 2009
Filing Date:
March 15, 2007
Export Citation:
Assignee:
TRUSTEES OF TUFTS COLLEGE
International Classes:
C07H7/027; A61K31/7012; A61K49/00; A61P1/00; A61P3/10; A61P5/14; A61P7/04; A61P9/00; A61P9/10; A61P11/00; A61P11/02; A61P11/06; A61P11/08; A61P13/00; A61P13/08; A61P13/12; A61P15/00; A61P17/00; A61P17/06; A61P17/16; A61P17/18; A61P19/02; A61P19/06; A61P25/00; A61P27/02; A61P29/00; A61P31/04; A61P31/10; A61P31/12; A61P35/00; A61P35/04; A61P43/00
Attorney, Agent or Firm:
Yanagita Seiji
Go Sakuma
Go Sakuma