Title:
フルオロシチジン誘導体の製造プロセス
Document Type and Number:
Japanese Patent JP2012533618
Kind Code:
A
Abstract:
A process for making a capecitabine or its derivative comprising (a) reacting a compound of the formula (II): wherein each of R1 and R2 independently represents a hydroxyl protecting group, with an acylating agent of formula (III): X—C(═O)—R3, wherein X is an acyl activating group in an organic solvent to produce an acylated compound; (b) deprotecting the acylated compound to obtain the compound of formula (I); and (c) purifying the compound of formula (I) with a solvent.
Inventors:
Futsun-Chen
Huang Hong-Tsun
Huang Hong-Tsun
Application Number:
JP2012521599A
Publication Date:
December 27, 2012
Filing Date:
July 21, 2010
Export Citation:
Assignee:
Sino Farm Taiwan Limited
International Classes:
C07H19/067; C12P19/38; A61K31/7068; A61P35/00; C07B53/00
Attorney, Agent or Firm:
Koichi Tsujii
Sadao Kumakura
Atsushi Hakoda
Kenji Asai
Kazuo Yamazaki
Satsuki Ichikawa
Matsuda Nanae
Sadao Kumakura
Atsushi Hakoda
Kenji Asai
Kazuo Yamazaki
Satsuki Ichikawa
Matsuda Nanae
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