Title:
FO-3216 SUBSTANCE AND ITS PRODUCTION
Document Type and Number:
Japanese Patent JPH07242636
Kind Code:
A
Abstract:
PURPOSE: To produce a new compound having an acyl coenzyme A cholesterol transferase inhibitory effect and useful for prevention and therapy of diseases, e.g. human hyperlipidemia caused by accumulation of cholesterol and adult diseases such as arteriosclerosis.
CONSTITUTION: A compound is expressed by formula I (R is H or COCH3; Y is OH, OCOCH3 or O; X is O or NCH2CH2OH; the dotted line represents a single bond or a double bond), e.g. the compound of formula II. The compound of formula I can be produced by culturing a microorganism belonging to Penicillium preferably Penicillium sp. FO-3216 (FERM-P-14152) preferably at pH5 and 27°C for 1 to 2 days.
Inventors:
OMURA SATOSHI
SHIOMI KAZURO
KODA HIROSHI
MASUMA ROKUROU
SHIOMI KAZURO
KODA HIROSHI
MASUMA ROKUROU
Application Number:
JP3148794A
Publication Date:
September 19, 1995
Filing Date:
March 01, 1994
Export Citation:
Assignee:
KITASATO INST
International Classes:
C12N9/99; A61K31/35; A61K31/352; A61K31/47; A61K31/472; A61K35/74; A61K36/062; A61P3/06; A61P9/10; A61P43/00; C07D217/04; C07D311/76; C12N1/14; C12P17/06; C12P17/12; C12R1/80; (IPC1-7): C07D217/04; A61K31/35; A61K31/47; A61K35/74; C07D311/76; C12N1/14; C12N9/99; C12P17/06; C12P17/12
Attorney, Agent or Firm:
Kazunori Kobayashi