Title:
Formless levonorgestrel and solid dispersing elements and those manufacturing methods
Document Type and Number:
Japanese Patent JP6125547
Kind Code:
B2
Abstract:
Provided are a new form of levonorgestrel, which is useful as an emergency contraception, etc., a solid dispersion of levonorgestrel, a manufacturing method for the same, and a drug composition. The differential scanning calorimetry spectrum of this amorphous levonorgestrel has an exothermic peak at 51-61℃. This solid dispersion contains levonorgestrel dispersed in an amorphous state in a polymer. Said polymer may be a pharmaceutically acceptable water-soluble polymer. The weight ratio of the polymer to the levonorgestrel may be, in terms of polymer/levonorgestrel, 90/10-50/50.
Inventors:
Shigeki Iwashita
Hiroyuki Hayashi
Takayoshi Nakagawa
Koichi Miyazaki
Hiroyuki Hayashi
Takayoshi Nakagawa
Koichi Miyazaki
Application Number:
JP2014561677A
Publication Date:
May 10, 2017
Filing Date:
April 23, 2014
Export Citation:
Assignee:
Aska Pharmaceutical Co., Ltd.
International Classes:
C07J1/00; A61K9/14; A61K31/567; A61K47/38; A61P15/18
Domestic Patent References:
| JP2007508287A | ||||
| JP5500510A |
Other References:
Piyush Jain 外1名著、 Inhibition of crystallization in drug-in-adhesive-type transdermal patches、 International Journal of Pharmaceutics、 ELSEVIER、 2010年、 第68~74頁
Piyush Jain 外1名著、 Induction and Inhibition of Crystallization in drug-in-adhesive-type transdermal patches、 Pharmaceutical Research、Springer、 2013年、 vol.30、 Issue 2、 第562~571頁
川上亘作監修、難水溶性薬物の物性評価と製剤設計の新展開、株式会社シーエムシー出版、2010年1月29日発行、第213~224頁
Piyush Jain 外1名著、 Induction and Inhibition of Crystallization in drug-in-adhesive-type transdermal patches、 Pharmaceutical Research、Springer、 2013年、 vol.30、 Issue 2、 第562~571頁
川上亘作監修、難水溶性薬物の物性評価と製剤設計の新展開、株式会社シーエムシー出版、2010年1月29日発行、第213~224頁
Attorney, Agent or Firm:
Mitsuo Kata