Title:
有機溶媒中および乾燥状態のペプチドの安定化における製剤の戦略
Document Type and Number:
Japanese Patent JP2006514914
Kind Code:
A
Abstract:
The invention relates to stabilized formulations of therapeutically active peptides, particularly PACAP 66. Formulations of the invention include a peptide containing at least one histidine residue, a transition metal salt and an organic solvent. The above formulations may contain peptides that have at least one asparagine residue and are acidified and dried (such as spray-dried or freeze-dried) before formulation preparation. Other formulations of the invention relate to stabilized formulations of PACAP 66 or peptides containing an asparagine residue, which are acidified and dried (such as spray-died or freeze-dried) with or without a transition metal salt.
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Inventors:
Wang, way
Wang, You-Chi Young Jiyoung
Martin-Moh, Sieriru
Wang, You-Chi Young Jiyoung
Martin-Moh, Sieriru
Application Number:
JP2003567931A
Publication Date:
May 18, 2006
Filing Date:
February 14, 2003
Export Citation:
Assignee:
Bayer Pharmaceuticals Corporates Corporation
International Classes:
A61K38/00; A61K9/19; A61K33/24; A61K38/22; A61K47/02; A61K47/10; A61K47/12; A61K47/14; A61K47/18; A61K47/20; A61K47/22; A61K47/34; A61P3/10; C07K14/575
Domestic Patent References:
| JPH107583A | 1998-01-13 | |||
| JP2000515131A | 2000-11-14 | |||
| JPH10503198A | 1998-03-24 | |||
| JPH09315997A | 1997-12-09 |
Foreign References:
| WO1998056426A1 | 1998-12-17 | |||
| WO2001023420A2 | 2001-04-05 | |||
| WO2001024817A2 | 2001-04-12 |
Attorney, Agent or Firm:
Heikichi Odashima