Title:
FORMULATION OF NANOSTRUCTURED GELS FOR INCREASED AGENT LOADING AND ADHESION
Document Type and Number:
Japanese Patent JP2023041861
Kind Code:
A
Abstract:
To provide formulations of nanostructured gels for increased agent loading and adhesion.SOLUTION: A gel formulation has been developed which provides high loading, e.g., between about 5% wt./wt. agent/total gel weight and about 50% wt./wt. agent/total gel weight, of a wide range of agents, especially amine-containing compounds such as local anesthetic agents that are known to be difficult to encapsulate, and which adhere to charged surfaces. Examples of pharmaceutically important amines include anesthetics, such as lidocaine. Tuning the ionic strength of an aqueous medium during preparation, suspension, and dialysis purification of the hydrogel composition allows for retention and/or control of agent loading contents, as well as a high capacity for adhesion to charged surfaces mimicking inflamed tissue. In some instances, the rheological properties of the gel can be tuned such as to impart thixotropic properties to the gels formed.SELECTED DRAWING: None
Inventors:
Derekji. Van der Pol
Dominique Jay. Brush Ori
Gregory Tea. Zgates
Dominique Jay. Brush Ori
Gregory Tea. Zgates
Application Number:
JP2023014533A
Publication Date:
March 24, 2023
Filing Date:
February 02, 2023
Export Citation:
Assignee:
Alivio Therapeutics, Incorporated
International Classes:
A61K9/06; A61K9/70; A61K31/167; A61K31/216; A61K31/245; A61K31/4458; A61K31/47; A61K45/00; A61K47/02; A61K47/10; A61K47/14; A61K47/20; A61K47/22; A61K47/26; A61L15/20; A61L15/44; A61P23/00
Attorney, Agent or Firm:
Shusaku Yamamoto
Morishita Natsuki
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto
Morishita Natsuki
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto