Title:
増大した薬剤負荷および接着のためのナノ構造化ゲルの製剤
Document Type and Number:
Japanese Patent JP7211974
Kind Code:
B2
Abstract:
A gel formulation has been developed which provides high loading, e.g., between about 5% and about 50% wt/wt agent/total gel weight, of a wide range of agents, especially amine-containing compounds such as local anesthetic agents that are known to be difficult to encapsulate, and which adhere to charged surfaces. Examples of pharmaceutically important amines include anesthetics, such as lidocaine. Tuning the ionic strength of an aqueous medium during preparation, suspension, and dialysis purification of the hydrogel composition allows for retention and/or control of agent loading contents, as well as a high capacity for adhesion to charged surfaces mimicking inflamed tissue. In some instances, the rheological properties of the gel can be tuned such as to impart thixotropic properties to the gels formed.
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Inventors:
Van der Pol, Derekji.
Brush Ori, Dominique Jay.
Zgates, Gregory Tea.
Brush Ori, Dominique Jay.
Zgates, Gregory Tea.
Application Number:
JP2019562349A
Publication Date:
January 24, 2023
Filing Date:
May 08, 2018
Export Citation:
Assignee:
Alivio Therapeutics, Incorporated
International Classes:
A61K47/46; A61K9/06; A61K9/10; A61K9/20; A61K9/48; A61K9/70; A61K31/167; A61K45/00; A61K45/06; A61K47/02; A61K47/10; A61K47/14; A61K47/20; A61K47/22; A61K47/26; A61P23/00; A61P29/00; A61P31/00; A61P31/04
Domestic Patent References:
| JP2013540757A | ||||
| JP2013523694A | ||||
| JP2019514957A | ||||
| JP2009525760A |
Foreign References:
| WO2017062818A1 |
Attorney, Agent or Firm:
Shusaku Yamamoto
Morishita Natsuki
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto
Morishita Natsuki
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto