Title:
環状化合物を含む製剤
Document Type and Number:
Japanese Patent JP5335677
Kind Code:
B2
Abstract:
This invention relates to the use of a cyclic compound of formula (I)
wherein A, B independently in each occurrence is alkane-i,j-diyl having k carbon atoms, i and independently j being less than or equal k and k being selected from 1 to 10, wherein said alkane-i,j-diyl (i) may comprise one or more double bonds; (ii) is optionally substituted; and/or (iii) comprises a cycle, wherein the total number of cycles being cyclic sugars in said compound is selected from 0 to 4 and is less than p-(n+m); X,Y independently in each occurrence is a biocompatible functional group comprising at least one oxygen atom or two sulphur atoms; n, m independently of each other are selected from 0 to 20; p is selected from 1 to 10; n+m is equal or greater than 1; and p-(n+m) is selected from 3 to 30; wherein said compound is capable of forming a complex with a protonated primary and/or protonated secondary amino group and/or a protonated guanidinium group for the manufacture of a pharmaceutical or diagnostic composition further comprising a pharmaceutically or diagnostically active agent, said active agent comprising one or more protonated primary and/or protonated secondary amino groups and/or a protonated guanidinium groups, wherein (a) transmembrane and/or transmucosal delivery; (b) solubility in non-aqueous solvents; and/or (c) stability of said active agent are improved.
Inventors:
Botti, paolo
Application Number:
JP2009529613A
Publication Date:
November 06, 2013
Filing Date:
September 27, 2007
Export Citation:
Assignee:
Botti, paolo
International Classes:
A61K47/48; A61K38/22; A61K47/22; A61K47/34; A61K47/42; A61P5/00; C07K11/02
Domestic Patent References:
| JP2006232909A | ||||
| JP2003503420A | ||||
| JP63501954A | ||||
| JP56008355A |
Foreign References:
| EP1219616A1 | ||||
| US4474753 |
Other References:
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DARWISH I.A.,INTERNATIONAL JOURNAL OF PHARMACEUTICS,1997年,V159,P207-213
DEGIM I.T.,INTERNATIONAL JOURNAL OF PHARMACEUTICS,1998年,V167,P229-231
ELKA TOUITOU,JOURNAL OF CONTROLLED RELEASE,NL,ELSEVIER,1992年 7月 1日,V21 N1/3,P139-144
HAMACHER K,THE JOURNAL OF NUCLEAR MEDICINE,米国,SOCIETY OF NUCLEAR MEDICINE,1986年 2月 1日,V27 N2,P235-238
MCGEARY R P,TETRAHEDRON,NL,ELSEVIER SCIENCE PUBLISHERS,2000年10月27日,V56 N44,P8703-8713
YANG D,JACS,2002年,V124 N42,P12410-12411
KLEIN E.,ANGEW.CHEM.INT.ED.,2005年,V44,P298-302
Attorney, Agent or Firm:
Yoshiyuki Kawaguchi
Mayuko Wakuda
Tsutomu Toyama
Shinichi Sanuki
Takeshi Niwa
Mayuko Wakuda
Tsutomu Toyama
Shinichi Sanuki
Takeshi Niwa