Title:
ヒトインシュリン様成長因子-1受容体に対する完全ヒト抗体
Document Type and Number:
Japanese Patent JP2007535895
Kind Code:
A
Abstract:
This invention relates to human antibodies that bind to human insulin-like growth factor-1 receptor (IGF-IR), to derivatives of these antibodies (Fabs, single chain antibodies, bi-specific antibodies, or fusion proteins), and to uses of the antibodies and derivatives in therapeutic, and diagnostic methods. The invention relates to nucleic acids encoding the anti-IGF-IR, methods of generating the antibodies and expression. The invention further relates to combination therapies using ant-IGF-IR antibodies with antineoplastic drugs.
Inventors:
Ludwig, Dale El.
Application Number:
JP2006514278A
Publication Date:
December 13, 2007
Filing Date:
May 03, 2004
Export Citation:
Assignee:
CORNELL RESEARCH FOUNDATION, INCORPORATED
International Classes:
C12N15/09; A61K31/4745; A61K31/7048; A61K39/395; A61P5/10; A61P17/06; A61P27/02; A61P35/00; A61P43/00; C07K16/28; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/13
Domestic Patent References:
| JP2006526388A | 2006-11-24 | |||
| JP2007528201A | 2007-10-11 | |||
| JP2005527222A | 2005-09-15 | |||
| JP2006517581A | 2006-07-27 |
Foreign References:
| WO2002053596A2 | 2002-07-11 |
Attorney, Agent or Firm:
Atsushi Aoki
Takashi Ishida
Fukumoto product
Tetsuji Koga
Kazumi Nakamura
Masaya Nishiyama
Takashi Ishida
Fukumoto product
Tetsuji Koga
Kazumi Nakamura
Masaya Nishiyama