Title:
ＢＤＮＦを含む融合蛋白質
Document Type and Number:
Japanese Patent JP7072524
Kind Code:
B2
Abstract:
The present invention provides a fusion protein of BDNF and an anti-human transferrin receptor antibody, in which in a heavy chain variable region of the antibody, (a) CDR1 includes an amino acid sequence of SEQ ID NO: 66 or SEQ ID NO: 67, (b) CDR2 includes an amino acid sequence of SEQ ID NO: 13 or SEQ ID NO: 14, and (c) CDR3 includes an amino acid sequence of SEQ ID NO: 15 or SEQ ID NO: 16.
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Inventors:
Hiroyuki Sonoda
Kenichi Takahashi
Kenichi Takahashi
Application Number:
JP2018559532A
Publication Date:
May 20, 2022
Filing Date:
December 26, 2017
Export Citation:
Assignee:
jcr pharma corporation
International Classes:
C12N15/62; A61K38/02; A61K47/68; A61P9/00; A61P25/00; A61P25/02; A61P25/04; A61P25/08; A61P25/14; A61P25/16; A61P25/18; A61P25/22; A61P25/24; A61P25/28; A61P27/02; C07K14/52; C07K16/28; C07K19/00; C12N5/10; C12N15/13; C12N15/19; C12N15/63
Foreign References:
| WO2015098989A1 | ||||
| US20100077498 |
Other References:
ZHOU Q. et al.,Monoclonal Antibody-Glial-Derived Neurotrophic Factor Fusion Protein Penetrates the Blood-Brain Barrier in the Mouse,Drug Metabolism and Disposition,2010年,Vol. 38, No. 4,p. 566-572
WU, D., and PARDRIDGE, W. M.,Neuroprotection with noninvasive neurotrophin delivery to the brain,Proceedings of the National Academy of Sciences of the United States of America,1999年01月,Vol. 96,p. 254-259
WU, D., and PARDRIDGE, W. M.,Neuroprotection with noninvasive neurotrophin delivery to the brain,Proceedings of the National Academy of Sciences of the United States of America,1999年01月,Vol. 96,p. 254-259
Attorney, Agent or Firm:
Yoshiki Hasegawa
Yoshinori Shimizu
Toshiaki Sakanishi
Yoshinori Shimizu
Toshiaki Sakanishi