Title:
G-CSFアナログ組成物および方法
Document Type and Number:
Japanese Patent JP2004524005
Kind Code:
A
Abstract:
The present invention relates to granulocyte colony stimulating factor ("G-CSF") analog polypeptide compositions, related nucleic acids, expression constructs, host cells, and processes for recombinant production of the present G-CSF analogs. The concept detailed herein involves novel mutants of G-CSF, using single substitutions to amino acids, which were rationally chosen to affect the cellular trafficking of G-CSF and/or G-CSFR. In addition, pharmaceutical compositions, and methods of use are provided.
Inventors:
Circer, Kasim Aye.
Raufenberger, Douglas A.
Raufenberger, Douglas A.
Application Number:
JP2002525774A
Publication Date:
August 12, 2004
Filing Date:
September 10, 2001
Export Citation:
Assignee:
Massachusetts Institute of Technology
International Classes:
C12N15/09; A61K38/00; A61K45/00; A61P7/00; A61P7/04; A61P7/06; A61P15/00; A61P25/00; A61P31/00; A61P31/18; A61P35/00; A61P37/00; A61P37/04; A61P43/00; C07K14/535; C12N1/19; C12N1/21; C12N5/078; C12N5/10; C12P21/02; C12Q1/02; (IPC1-7): C12N15/09; A61K38/00; A61K45/00; A61P7/04; A61P7/06; A61P31/00; A61P37/04; A61P43/00; C12N5/06; C12Q1/02
Domestic Patent References:
| JPH06100593A | 1994-04-12 | |||
| JPH04225998A | 1992-08-14 |
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita