Title:
擬似Ｑ２ペプチドを用いるＧＰＢＰ抑制
Document Type and Number:
Japanese Patent JP5883794
Kind Code:
B2
Abstract:
Disclosed are compounds of formula: that inhibiting GPBP activity, making them useful as therapeutics in antibody-mediated disorders, drug-resistant cancer, inflammation, protein misfolding and ER stress-mediated disorders, and aberrant apoptosis.
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Inventors:
South, fan
Fustello, Santos
Sants-Cerbera, Efe. Fan
Perez-Paya, Enrique
Brasco, Raul
Rebelto-Ross, Francisco
Revelt, Fernando
Fustello, Santos
Sants-Cerbera, Efe. Fan
Perez-Paya, Enrique
Brasco, Raul
Rebelto-Ross, Francisco
Revelt, Fernando
Application Number:
JP2012535688A
Publication Date:
March 15, 2016
Filing Date:
November 05, 2010
Export Citation:
Assignee:
FIBROSTATIN,SOCIEDAD LIMITADA
International Classes:
C07C59/11; A61K31/05; A61K31/11; A61K31/192; A61K31/216; A61K31/255; A61K31/4418; A61P17/00; A61P29/00; A61P35/00; A61P37/02; A61P37/06; C07C37/11; C07C39/12; C07C45/68; C07C47/565; C07C59/115; C07C65/24; C07C67/343; C07C69/708; C07C69/73; C07C69/732; C07D213/38; C07D213/48; C07D213/55
Domestic Patent References:
| JP2006525346A | ||||
| JP2008507498A | ||||
| JP2006342104A | ||||
| JP2008526910A |
Foreign References:
| WO1998004508A1 | ||||
| WO2002089738A1 | ||||
| WO2004071426A1 | ||||
| WO2009081195A1 | ||||
| WO2009008311A1 | ||||
| WO2009052126A1 | ||||
| WO2009043889A1 |
Other References:
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KISSEL, P. et al.,European Journal of Organic Chemistry,2009年,p.2953-2955
SCHONBERGER, F. et al.,Polymer,2009年,Vol.50,p.2010-2024
HUFNAGEL, F.,Zeitschrift fuer Naturforschung, Teil A: Astrophysik, Physik und Physikalische Chemie,1970年,p.1143-1150
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KISSEL, P. et al.,Chemistry - A European Journal,2009年,Vol.15,p.8955-8960
BANERJEE, S.,Journal of Polymer Materials,2007年,Vol.24, No.3,p.247-254
ANDREW D. HAMILTON,TERPHENYL-BASED BAK BH3 α-HELICAL PROTEOMIMETICS AS LOW-MOLECULAR-WEIGHT ANTAGONISTS OF BCL-XL,JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2005年,V127,P10191-10196
ANDREW D. HAMILTON,ANGEWANDTE CHEMIE INTERNATIONAL EDITION,2005年,V44,P2704-2707
ANDREW D. HAMILTON,TOWARD PROTEOMIMETICS: TERPHENYL DERIVATIVES AS STRUCTURAL AND FUNCTIONAL MIMICS 以下備考,JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2001年,V123,P5382-5383,OF EXTENDED REGIONS OF AN α-HELIX
AMES, G. R. and DAVEY, W.,Journal of the Chemical Society,1958年,p.1794-1799
BEDFORD, R. B. and LIMMERT, M. E.,Journal of Organic Chemistry,2003年,Vol.68,p.8669-8682
KISSEL, P. et al.,European Journal of Organic Chemistry,2009年,p.2953-2955
SCHONBERGER, F. et al.,Polymer,2009年,Vol.50,p.2010-2024
HUFNAGEL, F.,Zeitschrift fuer Naturforschung, Teil A: Astrophysik, Physik und Physikalische Chemie,1970年,p.1143-1150
FREUDENMANN, R. et al.,Synthetic Metals,2000年,Vol.111-112,p.441-443
RASHIDZADEH, B. et al.,ARKIVOC (Gainesville, FL, United States),2008年,p.167-172
RONAN, D. et al.,Organic Letters,2004年,Vol.6, No.6,p.885-887
CRAM, D. J. et al.,Journal of the American Chemical Society,1985年,Vol.107,p.3645-3657
KISSEL, P. et al.,Chemistry - A European Journal,2009年,Vol.15,p.8955-8960
BANERJEE, S.,Journal of Polymer Materials,2007年,Vol.24, No.3,p.247-254
ANDREW D. HAMILTON,TERPHENYL-BASED BAK BH3 α-HELICAL PROTEOMIMETICS AS LOW-MOLECULAR-WEIGHT ANTAGONISTS OF BCL-XL,JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2005年,V127,P10191-10196
ANDREW D. HAMILTON,ANGEWANDTE CHEMIE INTERNATIONAL EDITION,2005年,V44,P2704-2707
Attorney, Agent or Firm:
Hironobu Onda
Makoto Onda
Atsushi Honda
Makoto Onda
Atsushi Honda