To obtain a gel preparation composition which contains a hydrophilic copolymer of a specific structure, a polyhydric alcohol and a physiologically active substance and is prepared by crosslinking its hydrophilic copolymer, thus manifests excellent transdermal absorption.
This composition contains (A) a hydrophilic copolymer comprising (i) 10-90wt.% of a monomer unit bearing a carboxyl group, preferably (meth) acrylic acid and (ii) 90-10wt.% of other copolymerizable monomers, (B) a polyhydric alcohol and (C) a pharmacologically active substance, preferably at least one selected from progesterone, estradiol, testosterone, pindolol, clonidine, lidocaine and nifedipine and the component A is crosslinked. This composition is laminated to give a gel preparation. The amount of the component B is preferably 50-500 pts.wt., more preferably 100-400 pts.wt. per 100 pts.wt. of the component A, while the component C is preferably 5-100 pts.wt., more preferably 20-70 pts.wt.
OKABE HIDEAKI
KOGURE MASAO
SAITO TAKANORI
