Title:
野生型または変異型eNOSによる重症肢虚血の遺伝子療法
Document Type and Number:
Japanese Patent JP2005539031
Kind Code:
A
Abstract:
The present invention provides novel methods of preventing, diagnosing, and treating Critical Limb Ischemia (CLI), using eNOS polypeptides and polynucleotides to modulate eNOS activity in cells. Wild-type and mutant eNOS polypeptides, and polynucleotides encoding such polypeptides, are provided for use in the methods of the present invention. The eNOS mutant polypeptides of the present invention have at least one mutation corresponding to a site in a functional domain of a mammalian eNOS that is phosphorylated in cells.
Inventors:
Doll, William Pea.
Cowser, catalin
Kian, Hu Shen
Lebany, Gabor
Cowser, catalin
Kian, Hu Shen
Lebany, Gabor
Application Number:
JP2004529471A
Publication Date:
December 22, 2005
Filing Date:
August 15, 2003
Export Citation:
Assignee:
Schering Actien Gezel Shaft
International Classes:
A61K38/22; A61K38/27; A61K38/43; A61K48/00; A61P9/00; A61P9/08; C12N9/00; C12N9/02; C12N15/09; (IPC1-7): A61K48/00; A61K38/22; A61K38/27; A61K38/43; A61P9/00; A61P9/08
Domestic Patent References:
| JP2002506008A | 2002-02-26 |
Foreign References:
| WO2000062605A1 | 2000-10-26 |
Other References:
JOURNAL OF CONTROLLED RELEASE, vol. 78, JPN6009060775, January 2002 (2002-01-01), pages 285 - 294, ISSN: 0001473916
FEBS LETTERS, vol. 443, JPN6009060777, 1999, pages 285 - 289, ISSN: 0001473917
FEBS LETTERS, vol. 443, JPN6009060777, 1999, pages 285 - 289, ISSN: 0001473917
Attorney, Agent or Firm:
Atsushi Aoki
Takashi Ishida
Fukumoto product
Tetsuji Koga
Kazuhiro Nakamura
Masaya Nishiyama
Takashi Ishida
Fukumoto product
Tetsuji Koga
Kazuhiro Nakamura
Masaya Nishiyama