Title:
GENETIC POLYMORPHISMS ASSOCIATED WITH LIVER FIBROSIS, AND METHODS OF DETECTION AND USES THEREOF
Document Type and Number:
Japanese Patent JP2018023392
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To improve pharmaceutical agent design and therapy.SOLUTION: The present invention is based on the discovery of genetic polymorphisms that are associated with liver fibrosis and related pathologies. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid molecules and proteins as well as methods of using the reagents for detecting them. In one embodiment, the present invention relates to identification of novel SNPs, unique combinations of such SNPs and haplotypes of the SNPs that are associated with liver fibrosis.SELECTED DRAWING: None
Inventors:
CARGILL MICHELE
HUANG HONGJIN
HUANG HONGJIN
Application Number:
JP2017176520A
Publication Date:
February 15, 2018
Filing Date:
September 14, 2017
Export Citation:
Assignee:
CELERA CORP
International Classes:
C12N15/09; C07K14/47; C07K16/18; C12Q1/25; C12Q1/68; G01N33/53
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Natsuki Morishita