Title:
GENETICALLY ENGINEERED GLUTAMINASE AND ITS USE IN ANTIVIRAL AND ANTICANCER THERAPY
Document Type and Number:
Japanese Patent JP3727635
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To provide a DNA encoding a therapeutically suitable glutaminase, a polypeptide having a therapeutically suitable glutaminase activity and their use in antiviral and anticancer therapy.
SOLUTION: The DNA encoding the therapeutically suitable glutaminase has been molecularly cloned. This allows one to obtain a polypeptide which is a therapeutically suitable glutaminase free of contaminating endotoxin. It has been found that this polypeptide is a potent anti-viral agent and is a potent anti-cancer agent when coupled to an anti-tumor monoclonal antibody. The glutaminase of the present invention is particularly useful for treating lung, breast and colon cancer cells and in the treatment of HIV-infected cells.
Inventors:
Roberts, Joseph
Macalister, Thomas W.
Naturajan, Ceslaman
Freeman, Abbey Gee
Macalister, Thomas W.
Naturajan, Ceslaman
Freeman, Abbey Gee
Application Number:
JP2003420050A
Publication Date:
December 14, 2005
Filing Date:
December 17, 2003
Export Citation:
Assignee:
Roberts, Joseph
Medical Enchumes Akchen Gesell Shaft
Medical Enchumes Akchen Gesell Shaft
International Classes:
C12N15/09; A61K38/46; A61K48/00; A61P31/12; A61P35/00; C12N9/80; (IPC1-7): C12N15/09; C12N9/80
Other References:
Joseph ROBERTS, J. Biol. Chem., 1976, Vol.251, No.7, pages 2119-2123
Attorney, Agent or Firm:
Shoichi Okuyama
Arihara Koichi
Matsushima Tetsuo
Arihara Koichi
Matsushima Tetsuo
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