To obtain a new derivative which is a glucose or a mannose derivative labeled with a radioactive or nonradioactive iodine and useful as a radiodiagnostic agent, etc., capable of reflecting the sugar uptake by a sugar metabolic and a sugar transport systems of an animal cell, especially in the cell.
This new glucose or mannose derivative is represented by the formula (R1 is OH or methoxy; R2 is H or a halogen; R3 is H, OH or a halogen; R4 is a radioactive or a nonradioactive iodine) (e.g. 2,6-dideoxy-2-fluoro-6-iodo-D- glucose) and useful for a radiodiagnosis, diagnosis of a morbid state of an organ or a tissue and detection, etc., of tumor reflecting the sugar uptake by a sugar metabolic and a sugar transport systems of an animal cell including a human, especially in the cell with a sugar transport carrier present in a cell membrane. The compound is obtained by triacetylating 2-fluoro-2-deoxyglucose with acetic anhydride, then reacting the resultant compound with imidazole, triphenylphosphine and iodine, carrying out the iodination and subsequently deacetylating the prepared compound.
KAJI NORIHIRO
FUJIWARA MASAAKI
MINOSAKO YOSHITO
HAYASHI AKIO
