PURPOSE: To provide a new glycolic acid derivative and its salt usable as medicinally active substance for disease of cardia, circulatory organ and blood vessel, especially for prevention and treatment of hypertension, cardiac incompetence and high aldosteronism.
CONSTITUTION: The derivs. of glycolic acid represented by formula [where X is R8, R8-O-CmH2m-CO- ((m) is 0-10), R8-SO2-R9R10N-CmH2m-CO-, etc.; R1, R3, R6, R7, R9 and R10 are H, A (A is a 1-8 alkyl); R2, R4 and R8 are H, A, Ar, Ar-alkyl, Het (Het is a 5- or 6-membered heterocyclicring); R5 is (H, OH), (H, NH2) or =O; Y is 0 or 1 of residual group of amino acid selected from among Abu, Ada, Ala, Bia, etc.; Z is -CN, etc.] and the salts thereof, e.g. N-[2- isopropyl-4-hydroxy-5-(4-aminopiperidinocarbonyl-Pla-His-amino)-6- cyclohexylhexyl]-propanesulfonamide. The compd. represented by formula I is obtained, for example by treating a kind of derivative of the compd. represented by formula I having a functional group with a solvolysis agent, etc.
KURAUSU YOTSUTO SHIYUMITSUCHIE
KURAUSUUOTSUTOO MINKU
