ゴナドトロピン放出ホルモン受容体拮抗薬およびそれに関連する方法

Japanese Patent JP5735799

B2

GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure:wherein R1a, R1b, R1c, R1d, R2, R2a, and A are as defined herein, including stereoisomers, esters, solvates and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.

WO/1996/018642	AMINO ACIDS FOR MAKING BETIDES AND METHODS OF SCREENING AND MAKING BETIDE LIBRARIES
JP5180829	New polycyclic compound

Beaton, Graham
Chen, Me
Coon, Timothy Richard
Ewing, Todd
Qian, Won Long
Raw, Richard
Molly, willie
Smith, nicole
Wade, Warren
Chao, Lillen
Chu, Yun-Fay
Low bottom, martin
Ash Week, Neil

JP2010502325A

June 17, 2015

April 04, 2008

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Neurocline Biosciences, Inc.

C07C235/42; A61K31/44; A61K31/4439; A61K31/444; A61K31/47; A61K31/496; A61K31/505; A61K31/519; A61K31/5377; A61P1/04; A61P11/00; A61P13/02; A61P13/08; A61P15/00; A61P15/08; A61P15/14; A61P17/00; A61P35/00; C07C233/75; C07C255/57; C07D213/127; C07D213/61; C07D213/84; C07D213/89; C07D215/06; C07D215/14; C07D215/54; C07D239/36; C07D401/04; C07D401/12; C07D409/12; C07D411/12; C07D413/12; C07D495/04

JP2004509064A
JP2005225860A
JP2004514670A
JP2005097276A

WO2006118155A1
WO2006083005A1
WO2007046392A1
WO2006044975A1
US20070004701

Canadian Journal of Chemistry,2000年,78(6),905-919

Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita

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