粒状無細胞組織マトリックス

Japanese Patent JP5226914

B2

A method of processing an acellular tissue matrix to give a particulate acellular tissue matrix includes: cutting sheets of dry acellular tissue matrix into strips; cryofracturing the dry acellular tissue matrix strips at cryogenic temperatures; separating the resulting particles by size at cryogenic temperatures; and freeze drying the fraction of particles of desired size to remove any moisture that may have been absorbed to give a dry particulate acellular tissue matrix. Rehydration of the dry particulate acellular tissue matrix may take place just prior to use. The particulate acellular tissue may be applied to a recipient site, by way of injection, spraying, layering, packing, in-casing or combinations thereof. The particulate acellular tissue may further include growth and stimulating agents selected from epidermal growth factor, fibroblast growth factor, nerve growth factor, keratinocyte growth factor, platelet derived growth factor, vasoactive intestinal peptide, stem cell factor, bone morphogetic proteins, chondrocyte growth factor and combinations thereof. Other pharmaceutically active compounds may be combined with the rehydrated particulate material including: analgesic drugs; hemostatic drugs; antibiotic drugs; local anesthetics and the like to enhance the acceptance of the implanted particulate material. The particulate material product may also be combined with stem cells selected from mesenchymal stem cells, epidermal stem cells, cartilage stem cells, hematopoietic stem cells and combinations thereof.

JP6328146	Compositions and Methods for the Treatment of Neurodegeneration and Other Diseases
JP2002510612	INDUSTRIAL APPLICABILITY Maximizing the efficacy of substances used for improving health and well-being.

Glufy Edward S
Rivsey Steven A
Schiff Charles M
Bear Boom Lawrence E

JP2000554350A

July 03, 2013

June 18, 1999

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Life Cell Corporation

A61K9/14; A61K9/19; A61K35/28; A61K35/32; A61K35/36; A61K38/00; A61K38/18; A61K38/22; A61K45/00; A61L15/64; A61L27/24; A61L27/36; A61L27/38; A61L31/00; A61P17/02; C08H1/06; C08L89/06; C09H9/04; A61K35/12

JP7509638A
JP6261933A

Minoru Nakamura
Fumiaki Otsuka
Sadao Kumakura
Nobuo Ogawa
Takaki Nishijima
Atsushi Hakoda

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