PURPOSE: To suppress destruction of useful microorganism and to obtain the titled granule having improved shelf stability and uniform quality, by adding a binder having a specific melting point to a mold of useful microorganism or powder containing the mold and stirring and granulating the mixture in a non-aqueous system while melting the binder under heating.

CONSTITUTION: A mold of useful microorganism such as yeast, lactic acid bacteria, etc., or powder containing the mold is blended with preferably 15W30wt% binder (e.g. sucrose higher fatty acid ester, etc.) having 35W100°C melting point, stirred and granulated at the melt temperature of the binder in an non-aqueous system to give the aimed granule. A method wherein the binder is melted and sprayed is preferable because the blend can be granulated in a short time.