Title:
GUANIDINE DERIVATIVE*ITS MANUFACTURE AND SECRETION CONTROLLING PHARMACEUTICAL COMPOSITION CONTAINING IT
Document Type and Number:
Japanese Patent JPS54132566
Kind Code:
A
Abstract:
The guanidine derivative has the formula:where X is O or S: Y is N, CH or CCH3: m is O or 1: R1 is hydrogen and R2 cyano, trifluoroacetyl, C1-5 alkanoyl, 4,5-dihydro-4-oxothiazol-2-yl or A-B where A is 3,4-dioxocy- cbbutene-1,2-diyl or C=Z where Z is oxygen, sulphur, NCN. NNO2, CHNO2, NCONH2, C(CN)2, NCOR°, NCO2R°, NSO2R° or NR7 where R° is C1-6 alkyl and R7 is hydrogen or C1-6 alkyl and B is C1-6 alkyl, alkoxy or alkylthio or NR8R9 where R8 and R9 are hydrogen, C1-10 alkyl, C3-10-alkenyl, alkynyi or alkoxyalkyl, C2-6 (primary hydroxy)alkyl, or, when R9 is hydrogen, R8 is 2-](5-dimethylaminomethylfuran-2-yl[methylthio[-ethylamino or R8 and R9 are together a 5- or 6-membered non-aromatic ring optionally containing an additional N or O; or R1 and R2 are together imidazolidin-2-ylidene: R3 is hydrogen or fluorine: R4 is halogen or methyl: R5 is hydrogen, C1-6 alkyl or C3-10 alkoxyalkyl: and the salts thereof.
Inventors:
DERITSUKU FURIITO JIYOONZU
KEITO OORUDOHAMU
KEITO OORUDOHAMU
Application Number:
JP346779A
Publication Date:
October 15, 1979
Filing Date:
January 18, 1979
Export Citation:
Assignee:
ICI LTD
International Classes:
C07D277/20; A61K31/42; A61K31/421; A61K31/425; A61K31/426; A61K31/44; A61K31/535; A61K31/5377; A61P1/04; C07C335/28; C07D263/48; C07D271/07; C07D277/48; C07D285/08; C07D417/10; C07D417/12; C07D271/06; (IPC1-7): C07D277/48; C07D263/48; C07D285/08; C07D417/10; C07D417/12; A61K31/42; A61K31/425; A61K31/44; A61K31/535