異種スパイクタンパク質を有するＨ５２ ＩＢＶワクチン

Japanese Patent JP7350864

B2

The present invention relates i.a. to an H52 IBV (infectious bronchitis virus) encoding for a heterologous S (spike) protein or fragment thereof. Further, the present invention relates to an immunogenic composition comprising said H52 IBV encoding for a heterologous S (spike) protein or fragment thereof. Furthermore, the present invention relates to methods for immunizing a subject comprising administering to such subject the immunogenic composition of the present invention. Moreover, the present invention relates to methods of treating or preventing clinical signs caused by IBV in a subject of need, the method comprising administering to the subject a therapeutically effective amount of an immunogenic composition according to the present invention.

WO/2004/092332	SARS VIRUS POLYPEPTIDES
WO/2022/014620	SARS-CoV-2 VACCINE
WO/1990/014422	RIBOSOMAL FRAMESHIFT SIGNALS AND USES

Kramer-Kure Anika
Mund Egbert Siegfried
Philip Hans-Christian

JP2021543581A

September 26, 2023

October 28, 2019

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Boehringer Ingelheim Vetmedica GmbH

C07K14/165; A61K39/215; A61P31/14; A61P37/04; C12N7/01

CN104694488A
CN103642759A

Virology Journal ,2017年,Vol.14 ,article No.109,https://virologyj.biomedcentral.com/articles/10.1186/s12985-017-0775-8参照
Biotechnology Letters ,2016年,Vol.38,pp.299-304,https://link.springer.com/article/10.1007/s10529-015-1973-3参照

Shinichiro Tanaka
Hiroyuki Suda
Kazuo Yamazaki
Satsuki Ichikawa
Hironobu Hattori
Nanae Matsuda
Toshio Takizawa

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