Title:
HCVNS-3セリンプロテアーゼインヒビター
Document Type and Number:
Japanese Patent JP5248783
Kind Code:
B2
Abstract:
Methods drawn to peptidomimetic compounds which inhibit the NS3 protease of the hepatitis C virus (HCV), are described. The compounds have the formula (VI) where the variable definitions are as provided in the specification. The compounds comprise a carbocyclic P2 unit in conjunction with a novel linkage to those portions of the inhibitor more distal to the nominal cleavage site of the native substrate, which linkage reverses the orientation of peptidic bonds on the distal side relative to those proximal to the cleavage site.
Inventors:
Author Rosenquist
Fredrick Tolstenson
Pale-Ola Johansson
Ingemar Kvarung Strem
Susana Ayesa
Viern krason
Lazlo Lacos
Bertil Samuelson
Fredrick Tolstenson
Pale-Ola Johansson
Ingemar Kvarung Strem
Susana Ayesa
Viern krason
Lazlo Lacos
Bertil Samuelson
Application Number:
JP2006551000A
Publication Date:
July 31, 2013
Filing Date:
January 28, 2005
Export Citation:
Assignee:
Mediville Actie Borrag
International Classes:
C07D207/12; C07C235/40; C07C237/04; C07C237/10; C07C247/04; C07C271/22; C07C281/02; C07C309/73; C07C311/51; C07D207/16; C07D215/22; C07D215/233; C07D245/04; C07D277/20; C07D277/42; C07D333/20; C07D333/48; C07D333/54; C07D401/12; C07D401/14; C07D405/12; C07D405/14; C07D409/14; C07D413/14; C07D417/04; C07D417/14; C07D487/04; C07K5/02; C07K5/06; C07K5/065; A61K31/121; A61K31/136; A61K31/15; A61K31/155; A61K31/16; A61K31/198; A61K31/381; A61K31/40; A61K31/426; A61K31/4439; A61K31/47; A61K31/4709; A61K31/497; A61K31/63; A61K31/7052; A61K31/74; A61K38/21; A61K45/00; A61P31/14; C07C47/21; C07D
Domestic Patent References:
| JP2000502332A | ||||
| JP2002522554A | ||||
| JP2007519716A | ||||
| JP11292840A | ||||
| JP4210996A |
Foreign References:
| US5340801 | ||||
| US20030186895 | ||||
| EP0126587A1 |
Other References:
Zanotti, Giancarlo,Synthesis of analogs of amaninamide, an amatoxin from the white Amanita virosa mushroom,International Journal of Peptide & Protein Research,1987年,30(4),450-9
Zanotti, Giancarlo,Analogs of amanin,International Journal of Peptide & Protein Research,1981年,18(2),162-8
Zanotti, Giancarlo,Analogs of amanin,International Journal of Peptide & Protein Research,1981年,18(2),162-8
Attorney, Agent or Firm:
Shinjiro Ono
Kazuo Shamoto
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Takumi Terachi
Kazuo Shamoto
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Takumi Terachi