Title:
ＨＤＡＣ６阻害剤及び造影剤
Document Type and Number:
Japanese Patent JP7183178
Kind Code:
B2
Abstract:
Provided herein are compounds useful for binding to one or more histone deacetylase enzymes (HDACs). The present application further provides radiolabeled compounds useful as a radiotracer for position emission tomography imaging of HDAC. Methods for prepared unlabeled and labeled compounds, diagnostic methods, and methods of treating diseases associated HDAC are also provided.
Inventors:
Rocca, Johanna Carlina
Hooker, jacob
One, Changnin
Strible-Bantillo, Martin Georg
Hooker, jacob
One, Changnin
Strible-Bantillo, Martin Georg
Application Number:
JP2019555586A
Publication Date:
December 05, 2022
Filing Date:
April 11, 2018
Export Citation:
Assignee:
The General Hospital Corporation
International Classes:
C07C259/10; A61K31/166; A61K51/04; A61P7/00; A61P11/00; A61P25/00; A61P25/14; A61P25/18; A61P25/24; A61P25/28; A61P29/00; A61P35/00; A61P35/02; A61P37/06; A61P43/00; C07B59/00
Domestic Patent References:
| JP2013542994A |
Foreign References:
| US20150359794 | ||||
| US4205085 | ||||
| WO2011106632A1 | ||||
| WO2011058582A1 | ||||
| WO2010043953A2 | ||||
| US20060052599 | ||||
| WO2014059306A1 | ||||
| WO2015058106A1 | ||||
| WO2016018795A1 |
Other References:
Registry(STN)[online],2011年09月20日,CAS登録番号 1332894-18-4
Registry(STN)[online],1984年11月16日,CAS登録番号 73779-41-6
Registry(STN)[online],2016年02月28日,CAS登録番号 1875612-53-5
Registry(STN)[online],2016年02月05日,CAS登録番号 1860746-44-6
KATTAR, S. D. et al.,Parallel medicinal chemistry approaches to selective HDAC1/HDAC2 inhibitor(SHI-1:2) optimization,Bioorganic & Medicinal Chemistry Letters,2009年,Vol.19,pp.1168-1172,DOI:10.1016/j.bmcl.2008.12.083
HENDRICKS, J. A. et al.,In vivo PET imaging of histone deacetylases by 18F-suberoylanilide hydroxamic acid(18F-SAHA),Journal of Medicinal Chemistry,2011年,Vol.54,pp.5576-5582,DOI:10.1021/jm200620f
Registry(STN)[online],1984年11月16日,CAS登録番号 73779-41-6
Registry(STN)[online],2016年02月28日,CAS登録番号 1875612-53-5
Registry(STN)[online],2016年02月05日,CAS登録番号 1860746-44-6
KATTAR, S. D. et al.,Parallel medicinal chemistry approaches to selective HDAC1/HDAC2 inhibitor(SHI-1:2) optimization,Bioorganic & Medicinal Chemistry Letters,2009年,Vol.19,pp.1168-1172,DOI:10.1016/j.bmcl.2008.12.083
HENDRICKS, J. A. et al.,In vivo PET imaging of histone deacetylases by 18F-suberoylanilide hydroxamic acid(18F-SAHA),Journal of Medicinal Chemistry,2011年,Vol.54,pp.5576-5582,DOI:10.1021/jm200620f
Attorney, Agent or Firm:
Hiroshi Kobayashi
Norio Omori
Sayaka Hirakawa
Yasuhito Suzuki
Norio Omori
Sayaka Hirakawa
Yasuhito Suzuki
Previous Patent: Ink composition for forming organic layer of semiconductor
Next Patent: Container system with locking system for hinged lid
Next Patent: Container system with locking system for hinged lid