To simply and economically produce the subject derivative, having a readily modifiable substituent group and useful as a production intermediate for physiologically active substances by reacting a phenol compound with a halogenothiocarbamating agent.
This compound is represented by formula I (R is a tri-lower alkylsilyl, a group represented by formula II (R1 is a lower alkoxy, cyano, a lower alkoxycarbonyl, etc.), etc.; V is a halogen), e.g. 4-(2-amino-1,1- dimethylethyl)phenoxy-tert-butyldimethylsilane. The objective derivative is preferably produced by reacting, e.g. a phenol compound represented by formula III with a halogenothiocarbamating agent, e.g. thiophosgene in the presence of a base in or without a solvent at -10 to +10°C for several min to 24hr.
ITO HIROYUKI
KONO KAZUHISA
YAMAMOTO TAKASHI
KATSUURA KIMIO
GREEN CROSS CORP
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