Title:
HEDGEHOG ANTAGONIST, AND METHOD AND USE CONCERNING IT
Document Type and Number:
Japanese Patent JP2008214356
Kind Code:
A
Abstract:
To prevent angiogenesis and to cure or prevent undesirable cell proliferation including a tumor.
The invention relates to a composition and a method for inhibiting a hedgehog route by using an antagonist for the hedgehog route, for example, a hedgehog antagonist to exhibit overexpression of gli when coming into contact with a cell or a hedgehog antagonist to stimulate formation of a surface-active substance when coming into contact with a lung cell. The hedgehog antagonist is selected from a small molecule of less than 2,000 daltons, a hedgehog antibody, a patched antibody, a smoothened antibody, a variant hedgehog protein, an antisense nucleic acid and a ribozyme.
Inventors:
DUDEK HENRYK
PEPICELLI CARMEN
KARAVANOV IRINA
PEPICELLI CARMEN
KARAVANOV IRINA
Application Number:
JP2008101692A
Publication Date:
September 18, 2008
Filing Date:
April 09, 2008
Export Citation:
Assignee:
CURIS INC
International Classes:
A61K45/00; G01N33/50; A61K31/137; A61K31/138; A61K31/4025; A61K31/496; A61K31/517; A61K31/56; A61K31/58; A61K31/7088; A61K38/00; A61K39/395; A61K48/00; A61P17/00; A61P17/02; A61P17/06; A61P17/08; A61P35/00; A61P37/08; A61P43/00; C07D239/91; C07D405/06; C07J69/00; C07J71/00; C07K16/18; C07K16/30; C12N5/06; C12N5/10; C12N15/09; C12Q1/68; G01N33/15; G01N33/574
Attorney, Agent or Firm:
Axis International Patent Business Corporation