Title:
Helicobacter pyloriの生育阻害剤およびその製造方法
Document Type and Number:
Japanese Patent JP5505298
Kind Code:
B2
Abstract:
Disclosed is an inhibitor of the growth of Helicobacter pylori, which comprises a culture supernatant of a plant-derived lactic acid bacterium having 16S rRNA comprising a nucleotide sequence depicted in any one of SEQ ID NO:1 to SEQ ID NO:4 or an extract from the culture supernatant. It becomes possible to provide a novel technique for inhibiting the growth of Helicobacter pylori without supplying living cells of Helicobacter pylori to the stomach.
Inventors:
Masanori Sugiyama
Application Number:
JP2010505728A
Publication Date:
May 28, 2014
Filing Date:
March 25, 2009
Export Citation:
Assignee:
Hiroshima University
International Classes:
A61K35/74; A23L33/135; A61K31/05; A61K35/747; A61K36/00; A61K36/185; A61K36/45; A61K36/73; A61K36/899; A61P1/04; A61P31/04; A61P35/00; C12N15/09; C12P1/04; A61K131/00
Domestic Patent References:
| JP2006042796A | 2006-02-16 | |||
| JP2005013211A | 2005-01-20 | |||
| JP2006042796A | 2006-02-16 | |||
| JP2005013211A | 2005-01-20 |
Foreign References:
| CN1660300A | 2005-08-31 | |||
| KR20040092276A | 2004-11-03 | |||
| CN1660300A | 2005-08-31 | |||
| KR20040092276A | 2004-11-03 |
Other References:
JPN6013037121; ＬＯＲＣＡ，Ｇ．Ｌ． ｅｔ ａｌ， Ｌａｃｔｏｂａｃｉｌｌｕｓ ａｃｉｄｏｐｈｉｌｕｓ ａｕｔｏｌｙｓｉｎｓ ｉｎｈｉｂｉｔ Ｈｅｌｉｃｏｂａｃｔｅｒ ｐｙｌｏｒｉ ｉｎ ｖｉｔｒｏ， Ｃｕｒｒ Ｍｉ
JPN6009019984; ＬＥＥ，Ｈ．Ｍ． ｅｔ ａｌ．: Ｊ Ｍｉｃｒｏｂｉｏｌ Ｂｉｏｔｅｃｈｎｏｌ Ｖｏｌ．１６， Ｎｏ．１０, 2006, ｐ．１５１３-７
JPN6013037122; ＲＯＫＫＡ，Ｓ． ｅｔ ａｌ， Ｉｎ ｖｉｔｒｏ ｇｒｏｗｔｈ ｉｎｈｉｂｉｔｉｏｎ ｏｆ Ｈｅｌｉｃｏｂａｃｔｅｒ ｐｙｌｏｒｉ ｂｙ ｌａｃｔｏｂａｃｉｌｌｉ ｂｅｌｏｎｇｉｎｇ ｔｏ ｔｈｅ Ｌ
JPN6013037123; ＣＨＡＴＴＥＲＪＥＥ，Ａ． ｅｔ ａｌ， Ｉｎｈｉｂｉｔｉｏｎ ｏｆ Ｈｅｌｉｃｏｂａｃｔｅｒ ｐｙｌｏｒｉ ｉｎ ｖｉｔｒｏ ｂｙ ｖａｒｉｏｕｓ ｂｅｒｒｙ ｅｘｔｒａｃｔｓ， ｗｉｔｈ ｅｎｈａ
JPN6013037125; ＶＯＲＡＶＵＴＨＩＫＵＮＣＨＡＩ，Ｓ．Ｐ． ｅｔ ａｌ， Ｉｎｈｉｂｉｔｏｒｙ ａｎｄ ｋｉｌｌｉｎｇ ａｃｔｉｖｉｔｉｅｓ ｏｆ ｍｅｄｉｃｉｎａｌ ｐｌａｎｔｓ ａｇａｉｎｓｔ ｍｕｌｔｉｐｌｅ
JPN6013037121; ＬＯＲＣＡ，Ｇ．Ｌ． ｅｔ ａｌ， Ｌａｃｔｏｂａｃｉｌｌｕｓ ａｃｉｄｏｐｈｉｌｕｓ ａｕｔｏｌｙｓｉｎｓ ｉｎｈｉｂｉｔ Ｈｅｌｉｃｏｂａｃｔｅｒ ｐｙｌｏｒｉ ｉｎ ｖｉｔｒｏ， Ｃｕｒｒ Ｍｉ
JPN6009019984; ＬＥＥ，Ｈ．Ｍ． ｅｔ ａｌ．， Ｉｓｏｌａｔｉｏｎ ｏｆ Ｌａｃｔｏｂａｃｉｌｌｕｓ ｐｌａｎｔａｒｕｍ ｆｒｏｍ Ｋｉｍｃｈｉ ａｎｄ ｉｔｓ ｉｎｈｉｂｉｔｏｒｙ ａｃｔｉｖｉｔｙ ｏｎ ｔｈｅ
JPN6013037122; ＲＯＫＫＡ，Ｓ． ｅｔ ａｌ， Ｉｎ ｖｉｔｒｏ ｇｒｏｗｔｈ ｉｎｈｉｂｉｔｉｏｎ ｏｆ Ｈｅｌｉｃｏｂａｃｔｅｒ ｐｙｌｏｒｉ ｂｙ ｌａｃｔｏｂａｃｉｌｌｉ ｂｅｌｏｎｇｉｎｇ ｔｏ ｔｈｅ Ｌ
JPN6013037123; ＣＨＡＴＴＥＲＪＥＥ，Ａ． ｅｔ ａｌ， Ｉｎｈｉｂｉｔｉｏｎ ｏｆ Ｈｅｌｉｃｏｂａｃｔｅｒ ｐｙｌｏｒｉ ｉｎ ｖｉｔｒｏ ｂｙ ｖａｒｉｏｕｓ ｂｅｒｒｙ ｅｘｔｒａｃｔｓ， ｗｉｔｈ ｅｎｈａ
JPN6013037125; ＶＯＲＡＶＵＴＨＩＫＵＮＣＨＡＩ，Ｓ．Ｐ． ｅｔ ａｌ， Ｉｎｈｉｂｉｔｏｒｙ ａｎｄ ｋｉｌｌｉｎｇ ａｃｔｉｖｉｔｉｅｓ ｏｆ ｍｅｄｉｃｉｎａｌ ｐｌａｎｔｓ ａｇａｉｎｓｔ ｍｕｌｔｉｐｌｅ
JPN6009019984; ＬＥＥ，Ｈ．Ｍ． ｅｔ ａｌ．: Ｊ Ｍｉｃｒｏｂｉｏｌ Ｂｉｏｔｅｃｈｎｏｌ Ｖｏｌ．１６， Ｎｏ．１０, 2006, ｐ．１５１３-７
JPN6013037122; ＲＯＫＫＡ，Ｓ． ｅｔ ａｌ， Ｉｎ ｖｉｔｒｏ ｇｒｏｗｔｈ ｉｎｈｉｂｉｔｉｏｎ ｏｆ Ｈｅｌｉｃｏｂａｃｔｅｒ ｐｙｌｏｒｉ ｂｙ ｌａｃｔｏｂａｃｉｌｌｉ ｂｅｌｏｎｇｉｎｇ ｔｏ ｔｈｅ Ｌ
JPN6013037123; ＣＨＡＴＴＥＲＪＥＥ，Ａ． ｅｔ ａｌ， Ｉｎｈｉｂｉｔｉｏｎ ｏｆ Ｈｅｌｉｃｏｂａｃｔｅｒ ｐｙｌｏｒｉ ｉｎ ｖｉｔｒｏ ｂｙ ｖａｒｉｏｕｓ ｂｅｒｒｙ ｅｘｔｒａｃｔｓ， ｗｉｔｈ ｅｎｈａ
JPN6013037125; ＶＯＲＡＶＵＴＨＩＫＵＮＣＨＡＩ，Ｓ．Ｐ． ｅｔ ａｌ， Ｉｎｈｉｂｉｔｏｒｙ ａｎｄ ｋｉｌｌｉｎｇ ａｃｔｉｖｉｔｉｅｓ ｏｆ ｍｅｄｉｃｉｎａｌ ｐｌａｎｔｓ ａｇａｉｎｓｔ ｍｕｌｔｉｐｌｅ
JPN6013037121; ＬＯＲＣＡ，Ｇ．Ｌ． ｅｔ ａｌ， Ｌａｃｔｏｂａｃｉｌｌｕｓ ａｃｉｄｏｐｈｉｌｕｓ ａｕｔｏｌｙｓｉｎｓ ｉｎｈｉｂｉｔ Ｈｅｌｉｃｏｂａｃｔｅｒ ｐｙｌｏｒｉ ｉｎ ｖｉｔｒｏ， Ｃｕｒｒ Ｍｉ
JPN6009019984; ＬＥＥ，Ｈ．Ｍ． ｅｔ ａｌ．， Ｉｓｏｌａｔｉｏｎ ｏｆ Ｌａｃｔｏｂａｃｉｌｌｕｓ ｐｌａｎｔａｒｕｍ ｆｒｏｍ Ｋｉｍｃｈｉ ａｎｄ ｉｔｓ ｉｎｈｉｂｉｔｏｒｙ ａｃｔｉｖｉｔｙ ｏｎ ｔｈｅ
JPN6013037122; ＲＯＫＫＡ，Ｓ． ｅｔ ａｌ， Ｉｎ ｖｉｔｒｏ ｇｒｏｗｔｈ ｉｎｈｉｂｉｔｉｏｎ ｏｆ Ｈｅｌｉｃｏｂａｃｔｅｒ ｐｙｌｏｒｉ ｂｙ ｌａｃｔｏｂａｃｉｌｌｉ ｂｅｌｏｎｇｉｎｇ ｔｏ ｔｈｅ Ｌ
JPN6013037123; ＣＨＡＴＴＥＲＪＥＥ，Ａ． ｅｔ ａｌ， Ｉｎｈｉｂｉｔｉｏｎ ｏｆ Ｈｅｌｉｃｏｂａｃｔｅｒ ｐｙｌｏｒｉ ｉｎ ｖｉｔｒｏ ｂｙ ｖａｒｉｏｕｓ ｂｅｒｒｙ ｅｘｔｒａｃｔｓ， ｗｉｔｈ ｅｎｈａ
JPN6013037125; ＶＯＲＡＶＵＴＨＩＫＵＮＣＨＡＩ，Ｓ．Ｐ． ｅｔ ａｌ， Ｉｎｈｉｂｉｔｏｒｙ ａｎｄ ｋｉｌｌｉｎｇ ａｃｔｉｖｉｔｉｅｓ ｏｆ ｍｅｄｉｃｉｎａｌ ｐｌａｎｔｓ ａｇａｉｎｓｔ ｍｕｌｔｉｐｌｅ
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