Title:
HEMATOPOIETIC CELL FROM HUMAN EMBRYONIC STEM CELL
Document Type and Number:
Japanese Patent JP2010075195
Kind Code:
A
Abstract:
To provide a system for producing a hematopoietic cell from human embryonic stem cells.
Differentiation is conducted in the presence of hematogenic cytokines and other factors. The cell population that is obtained is remarkably enriched in CD45+ve cells, a marker of early hematopoietic precursor with self-renewing capacity. Including a bone morphogenic protein during the differentiation process enhances the ability of the cell population to form secondary colonies. Because of the enormous replicative capacity of embryonic stem cells, this provides an important new commercial source of hematopoietic cells.
Inventors:
BHATIA MICKIE
MADRENAS JOAQUIN
FERBER IRIS A
MAJUMDAR ANISH SEN
MADRENAS JOAQUIN
FERBER IRIS A
MAJUMDAR ANISH SEN
Application Number:
JP2009265829A
Publication Date:
April 08, 2010
Filing Date:
November 24, 2009
Export Citation:
Assignee:
GERON CORP
ROBARTS RES INST
ROBARTS RES INST
International Classes:
C12N5/0789; C12N5/10; A61K35/12; A61K35/28; A61K35/48; A61K35/545; A61K45/00; A61K48/00; A61P7/00; A61P7/06; A61P29/00; A61P35/00; A61P35/02; A61P37/02; A61P37/06; A61P43/00; C12N5/06; C12N5/077; C12N5/078; C12N5/079; C12Q1/02; C12N15/873
Attorney, Agent or Firm:
Hatsushi Shimizu
Koichi Niimi
Koichi Niimi