Title:
肝細胞癌特異的プロモーターおよびその使用
Document Type and Number:
Japanese Patent JP2007508036
Kind Code:
A
Abstract:
Liver cancer, particularly hepatocellular carcinoma specific promoter sequences and adenovirus vehicles are provided. By providing for transcriptional initiating regulation dependent upon transcription factors that are only active in specific, limited cell types, virus replication will be restricted to the target cells. The modified adenovirus may be used as a vehicle for introducing new genetic capability, particularly associated with cytotoxicity, for treating neoplasia.
Inventors:
Arroyo, Torini
Lee, Yuan Hao
Lee, Yuan Hao
Application Number:
JP2006535513A
Publication Date:
April 05, 2007
Filing Date:
September 24, 2004
Export Citation:
Assignee:
Cell Genesys, Inc.
International Classes:
C12N15/09; A61K35/76; A61K35/761; A61K48/00; A61P31/14; A61P31/20; A61P35/00; C07H21/04; C12N1/15; C12N1/19; C12N1/21; C12N5/08; C12N5/10; C12N7/00; C12N15/861
Foreign References:
| WO2001073093A2 | 2001-10-04 | |||
| WO1998039465A2 | 1998-09-11 |
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita